Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

Aims Free fatty acids (FFA) can act as direct signalling molecules through activation of several membrane‐bound G‐protein coupled receptors. The FFA2 receptor (known as GPR43) is activated by short chain fatty acids (SCFA) such as acetate and has been shown to play a major role in SCFA‐induced neutr...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 82; no. 1; pp. 139 - 148
Main Authors:	Namour, Florence, Galien, René, Van Kaem, Tim, Van der Aa, Annegret, Vanhoutte, Frédéric, Beetens, Johan, Klooster, Gerben
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.07.2016
Subjects:	Adolescent Adult Butyrates - administration & dosage Butyrates - pharmacokinetics Butyrates - pharmacology Cell Movement - drug effects Dose-Response Relationship, Drug Double-Blind Method FFA2 GLPG0974 GPR43 healthy subjects Humans Male Middle Aged Neutrophil Activation - drug effects Pharmacokinetic Dynamic Relationships Receptors, Cell Surface - antagonists & inhibitors safety Thiophenes - administration & dosage Thiophenes - pharmacokinetics Thiophenes - pharmacology Young Adult FFA2 PD healthy subjects GPR43 safety PK GLPG0974
ISSN:	0306-5251, 1365-2125
Online Access:	Get full text
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