Microarray data and pathway analyses of peripheral blood mononuclear cells from healthy subjects after a three weeks grape-rich diet

Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differ...

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Vydáno v:	Data in brief Ročník 29; s. 105278
Hlavní autoři:	Milella, Rosa Anna, Gasparro, Marica, Alagna, Fiammetta, Cardone, Maria Francesca, Rotunno, Silvia, Ammollo, Concetta Tiziana, Semeraro, Fabrizio, Tullo, Apollonia, Marzano, Flaviana, Catalano, Domenico, Antonacci, Donato, Colucci, Mario, D'Elia, Domenica
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Inc 01.04.2020 Elsevier
Témata:	autophagy Biochemistry, Genetics and Molecular Biology biogenesis Biological processes diet Diets DNA gene expression Grape intake grapes Health benefits Human health humans immunity inflammation Microarray data microarray technology mitochondria non-coding RNA nutrigenomics Pathway analyses Peripheral blood mononuclear cells thrombosis Diets Grape intake Human health Pathway analyses Microarray data Biological processes Peripheral blood mononuclear cells Health benefits
ISSN:	2352-3409, 2352-3409
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Abstract	Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article “Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs” [1].
AbstractList	Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article “Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs” [1]. Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article "Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs" [1].Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article "Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs" [1]. Using Human Gene Expression Microarrays (Agilent) technologies, we investigated changes of the level of gene expression in peripheral blood mononuclear cells of healthy subjects after 21 days of fresh table grape-rich diet and after an additional 28-day washout. Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. Moreover, fresh grape intake was found to influence the expression of many long non-coding RNA genes. The data can be valuable for researchers interested in nutrigenetics and nutrigenomics studies and are related to the research article “Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on PBMCs” [1]. Keywords: Peripheral blood mononuclear cells, Microarray data, Pathway analyses, Biological processes, Grape intake, Diets, Human health, Health benefits
ArticleNumber	105278
Author	D'Elia, Domenica Cardone, Maria Francesca Gasparro, Marica Alagna, Fiammetta Rotunno, Silvia Antonacci, Donato Catalano, Domenico Semeraro, Fabrizio Colucci, Mario Milella, Rosa Anna Ammollo, Concetta Tiziana Tullo, Apollonia Marzano, Flaviana
AuthorAffiliation	d Institute for Biomedical Technology, National Research Council, 70126, Bari, Italy a Research Centre for Viticulture and Enology, Council for Agricultural Research and Economics, Turi, 70010, Bari, Italy c Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, 70126, Bari, Italy b Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124, Bari, Italy
AuthorAffiliation_xml	– name: c Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council, 70126, Bari, Italy – name: a Research Centre for Viticulture and Enology, Council for Agricultural Research and Economics, Turi, 70010, Bari, Italy – name: d Institute for Biomedical Technology, National Research Council, 70126, Bari, Italy – name: b Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124, Bari, Italy
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Keywords	Diets Grape intake Human health Pathway analyses Microarray data Biological processes Peripheral blood mononuclear cells Health benefits
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References	Milella, Gasparro, Alagna, Cardone, Rotunno, Ammollo, Semeraro, Tullo, Marzano, Catalano, Antonacci, Colucci, D'Elia (bib1) 2020; 64 Reimand, Arak, Adler, Kolberg, Reisberg, Peterson (bib2) 2016; 44 Milella (10.1016/j.dib.2020.105278_bib1) 2020; 64 Reimand (10.1016/j.dib.2020.105278_bib2) 2016; 44
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SubjectTerms	autophagy Biochemistry, Genetics and Molecular Biology biogenesis Biological processes diet Diets DNA gene expression Grape intake grapes Health benefits Human health humans immunity inflammation Microarray data microarray technology mitochondria non-coding RNA nutrigenomics Pathway analyses Peripheral blood mononuclear cells thrombosis
Title	Microarray data and pathway analyses of peripheral blood mononuclear cells from healthy subjects after a three weeks grape-rich diet
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