Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study

Background: Two novel systemic inflammation indices, SII and SIRI, are associated with increased risk of cardiovascular diseases (CVD). However, SII and SIRI are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. This study aim...

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Vydáno v:	Journal of inflammation research Ročník 15; s. 5945 - 5957
Hlavní autoři:	Li, Jun, He, Di, Yu, Jiazhou, Chen, Shuohua, Wu, Qiong, Cheng, Zongxue, Wei, Qiaohui, Xu, Yuying, Zhu, Yimin, Wu, Shouling
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Macclesfield Dove Medical Press Limited 01.01.2022 Taylor & Francis Ltd Dove Dove Medical Press
Témata:	2008 2010 were assessed by dynamic trajectories (primary exposure) 95% ci=1.01-1.25) while no significant association was found for ‘decrease pattern’. the highest group of annual siri increase and average siri had respective hr of 1.25(95% ci=1.09-1.44) and 1.39(95% ci=1.19-1.63). conclusion: dynamic status of sii and siri was significantly associated with risk of cvd 95% ci=1.17-1.63) and 12% (hr=1.12 adjusted hrs were 1.24(95% ci=1.02-1.51) for ‘increase pattern’ and 1.11(95% ci=1.00-1.23) for ‘moderate-stable pattern’ while the association was not significant for ‘decrease pattern’. additionally after controlling confounders and level of sii in 2006 and average value. the outcome was cvd incidence during 8.6 years’ follow-up. multiple cox regression models were used to calculate the adjusted hazard ratios (hrs) and confidence intervals (95%cis). results: four dynamic trajectories of sii and siri were identified as follows: low stable pattern and decrease pattern. for sii annual increase background: two novel systemic inflammation indices Biomarkers Blood Blood platelets Body mass index Cancer Cardiovascular disease Cardiovascular diseases Cholesterol Cohort analysis compared with ‘low stable pattern’ Diabetes Drug use Family medical history Heart attacks High density lipoprotein Hypertension increase pattern Inflammation Lymphocytes moderate stable pattern Neutrophils Oncology, Experimental Original Research Questionnaires Regression analysis Risk factors sii and siri are associated with increased risk of cardiovascular diseases (cvd). however sii and siri are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. this study aims to examine the association between the dynamic status of sii and siri and risk of cvd. methods: this prospective study included a total of 45809 subjects without mi Statistical analysis Stroke stroke and cancer prior to or in 2010 (baseline of this study). the dynamic status of sii and siri during 2006 the highest group of annual sii increase and average sii had respective hr of 1.20(95% ci=1.05-1.37) and 1.32(95% ci=1.13-1.55). the results were consistent for siri. ‘increase pattern’ and ‘moderate stable pattern’ increased the risk of cvd by 38%(hr=1.38 Variables which highlighted that we should focus on the dynamic change of sii and siri China
ISSN:	1178-7031, 1178-7031
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