The role of glutathione-S-transferase in anti-cancer drug resistance

Glutathione- S -transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and exogenous electrophilic compounds. GSTs are divided into two distinct super-family members: the membrane-bound microsomal and cyt...

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Bibliographic Details
Published in:	Oncogene Vol. 22; no. 47; pp. 7369 - 7375
Main Authors:	Townsend, Danyelle M, Tew, Kenneth D
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.10.2003 Nature Publishing Nature Publishing Group
Subjects:	Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Asthma Biological and medical sciences c-Jun protein Cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular stress response Chemotherapy Detoxification Drug development Drug resistance Drug Resistance, Neoplasm - drug effects Enzyme inhibitors Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Etiology Fundamental and applied biological sciences. Psychology Glutathione Glutathione transferase Glutathione Transferase - antagonists & inhibitors Glutathione Transferase - metabolism Human Genetics Humans Inactivation, Metabolic Internal Medicine Isoenzymes JNK protein Kinases Leukotrienes Ligands MAP kinase MAP Kinase Signaling System Medicine Medicine & Public Health Molecular and cellular biology Multiple sclerosis Neoplasms - drug therapy Neoplasms - enzymology Neurodegenerative diseases Oncology Oxidative stress Prostaglandins Protein interaction Proteins review Therapeutic targets Transcription factors Tumors MAP kinase pathway GST polymorphism resistance Resistance Enzyme Glutathione transferase Transferases Mitogen-activated protein kinase Malignant tumor Carcinogenesis Polymorphism
ISSN:	0950-9232, 1476-5594
Online Access:	Get full text
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