MMP12, Lung Function, and COPD in High-Risk Populations

A variant of MMP12, encoding a matrix metallopeptidase, is associated with increased lung function in children with asthma and in adult smokers. It is also associated with a decreased risk of chronic obstructive pulmonary disease in adult smokers. A variant of MMP12 is associated with increased lung...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 361; no. 27; pp. 2599 - 2608
Main Authors:	Hunninghake, Gary M, Cho, Michael H, Tesfaigzi, Yohannes, Soto-Quiros, Manuel E, Avila, Lydiana, Lasky-Su, Jessica, Stidley, Chris, Melén, Erik, Söderhäll, Cilla, Hallberg, Jenny, Kull, Inger, Kere, Juha, Svartengren, Magnus, Pershagen, Göran, Wickman, Magnus, Lange, Christoph, Demeo, Dawn L, Hersh, Craig P, Klanderman, Barbara J, Raby, Benjamin A, Sparrow, David, Shapiro, Steven D, Silverman, Edwin K, Litonjua, Augusto A, Weiss, Scott T, Celedón, Juan C
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 31.12.2009
Subjects:	Adult Aged Alleles Asthma - genetics Asthma - physiopathology Biological and medical sciences Child Chronic obstructive pulmonary disease, asthma Cohort Studies Disease management Emphysema Female Forced Expiratory Volume - genetics General aspects Genetic Markers Genetic Predisposition to Disease Humans Male Matrix Metalloproteinase 12 - genetics Medical research Medical sciences Middle Aged Pneumology Polymorphism, Single Nucleotide Promoter Regions, Genetic Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - physiopathology Risk factors Smoking - genetics Smoking - physiopathology Human Medicine Lung disease High risk Lung function Respiratory disease Bronchus disease Population Chronic obstructive pulmonary disease Obstructive pulmonary disease
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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