A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis

Cysteine palmitoylation (S-palmitoylation) is a reversible post-translational modification that is installed by the DHHC family of palmitoyltransferases and is reversed by several acyl protein thioesterases 1 , 2 . Although thousands of human proteins are known to undergo S-palmitoylation, how this...

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Bibliographic Details
Published in:	Nature (London) Vol. 586; no. 7829; pp. 434 - 439
Main Authors:	Zhang, Mingming, Zhou, Lixing, Xu, Yuejie, Yang, Min, Xu, Yilai, Komaniecki, Garrison Paul, Kosciuk, Tatsiana, Chen, Xiao, Lu, Xuan, Zou, Xiaoping, Linder, Maurine E., Lin, Hening
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.10.2020 Nature Publishing Group
Subjects:	14/19 14/35 38 38/109 38/70 38/77 631/250/256 631/45/607/1172 631/80/86 631/92/458 82 82/29 82/80 96 Cell activation Cell differentiation Colitis Cysteine Differentiation (biology) Disease Helper cells Humanities and Social Sciences Inflammatory bowel disease Inflammatory bowel diseases Intestine Kinases Lymphocytes T multidisciplinary Nuclei (cytology) Palmitoylation Perturbation Phosphorylation Plasma Post-translation Proteins Recruitment Science Science (multidisciplinary) Signaling Signs and symptoms Stat3 protein Stimulators Thioesterase
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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