The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study

•Tryptophan and kynurenines are related to inflammation and may be neuroactive.•Experimental studies indicates a role for the rate limiting enzyme IDO in cognition.•We assessed potential associations between kynurenines and cognition in 2174 older adults.•Lower cognitive performance is seen with hig...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 75; pp. 155 - 162
Main Authors:	Solvang, Stein-Erik Hafstad, Nordrehaug, Jan Erik, Tell, Grethe S., Nygård, Ottar, McCann, Adrian, Ueland, Per Magne, Midttun, Øivind, Meyer, Klaus, Vedeler, Christian A., Aarsland, Dag, Refsum, Helga, Smith, A. David, Giil, Lasse Melvaer
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.01.2019
Subjects:	Aged Biomarkers - blood Body Mass Index C-Reactive Protein - metabolism Cognition Cognition - physiology Controlled Oral Word Association Test Cross-Sectional Studies Female Hordaland Health Study Humans Independent Living Inflammation Inflammation - blood Kendrick Object Learning Test Kynurenine - blood Kynurenine - metabolism Kynurenine - physiology Kynurenines Male Neopterin - blood Neopterin - metabolism Neuropsychological Tests Signal Transduction - physiology Tryptophan - blood Tryptophan - metabolism Hordaland Health Study Controlled Oral Word Association Test Tryptophan metabolism Kendrick Object Learning Test Inflammation Cognition Kynurenines
ISSN:	0889-1591, 1090-2139, 1090-2139
Online Access:	Get full text
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