Effects of background suppression on the sensitivity of dual-echo arterial spin labeling MRI for BOLD and CBF signal changes

Dual-echo arterial spin labeling (DE-ASL) enables the simultaneous acquisition of BOLD and CBF fMRI data and is often used for calibrated BOLD and cerebrovascular CO2 reactivity measurements. DE-ASL, like all ASL techniques, suffers from a low intrinsic CBF SNR, which can be improved by suppressing...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Vol. 103; pp. 316 - 322
Main Authors: Ghariq, Eidrees, Chappell, Michael A., Schmid, Sophie, Teeuwisse, Wouter M., van Osch, Matthias J.P.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Inc 01.12.2014
Elsevier
Elsevier Limited
Subjects:
Adult
ASL
Background suppression
Biological and medical sciences
Blood
BOLD
Brain - blood supply
Brain Mapping - methods
Calibrated BOLD
Carbon dioxide
CBF
Cerebrovascular Circulation - physiology
Cerebrovascular reactivity
Cerebrovascular system
Dual-echo arterial spin labeling
Female
Functional magnetic resonance imaging
Fundamental and applied biological sciences. Psychology
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging
Male
Medical research
Noise
Physiology
Signal-To-Noise Ratio
Spin labeling
Spin Labels
Vertebrates: nervous system and sense organs
Visual stimuli
Cerebrovascular reactivity
Dual-echo arterial spin labeling
DE-ASL
Background suppression
Calibrated BOLD
CBF
BOLD
ASL
fSNR
Sensitivity
Nuclear magnetic resonance imaging
ISSN:1053-8119, 1095-9572, 1095-9572
Online Access:Get full text
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Summary:Dual-echo arterial spin labeling (DE-ASL) enables the simultaneous acquisition of BOLD and CBF fMRI data and is often used for calibrated BOLD and cerebrovascular CO2 reactivity measurements. DE-ASL, like all ASL techniques, suffers from a low intrinsic CBF SNR, which can be improved by suppressing the background signal via the inclusion of additional inversion pulses. However, until now this approach has been considered to be undesirable for DE-ASL, because the BOLD signal is extracted from the background signal and attenuating the background signal could decrease the sensitivity of DE-ASL scans for BOLD changes. In this study, the effect of background suppression on the sensitivity of DE-ASL MRI for BOLD and CBF signal changes with a visual stimulation paradigm was studied. Results showed that with an average background suppression level of 70% the BOLD sensitivity of DE-ASL MRI decreases slightly (15%), while the CBF sensitivity of the scans increased by almost a factor-of-two (81%). These findings support the conclusion that the gains in CBF sensitivity of DE-ASL MRI due to background suppression outweigh the slight decrease in sensitivity of these scans for BOLD changes, and thus that background suppression is highly recommended for DE-ASL. •Dual-echo ASL was used to acquire BOLD and CBF weighted fMRI data simultaneously.•Dual-echo ASL MRI suffered from a low intrinsic CBF SNR.•The low CBF SNR of dual-echo ASL improved with background suppression.•Background suppression was not detrimental for the BOLD SNR of dual-echo ASL.
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ISSN:1053-8119
1095-9572
1095-9572
DOI:10.1016/j.neuroimage.2014.09.051