Wnt signaling in cancer

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities....

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Veröffentlicht in:Oncogene Jg. 36; H. 11; S. 1461 - 1473
Hauptverfasser: Zhan, T, Rindtorff, N, Boutros, M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.03.2017
Nature Publishing Group
Schlagworte:
631/67
631/67/68
631/80/86
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
beta Catenin - metabolism
Cancer
Carcinogenesis
Cell Biology
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cellular signal transduction
Genetic aspects
Health aspects
Human Genetics
Humans
Internal Medicine
Medicine
Medicine & Public Health
Molecular Targeted Therapy
Mutation
Neoplasm Metastasis
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Oncogenes
Oncology
Protein Binding
Protein expression
Review
Signal transduction
Tumor Escape - immunology
Tumorigenesis
Wnt Proteins - metabolism
Wnt Signaling Pathway - drug effects
ISSN:0950-9232, 1476-5594, 1476-5594
Online-Zugang:Volltext
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Zusammenfassung:Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
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These authors contributed equally to this work.
ISSN:0950-9232
1476-5594
1476-5594
DOI:10.1038/onc.2016.304