Wnt signaling in cancer

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities....

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Vydané v:	Oncogene Ročník 36; číslo 11; s. 1461 - 1473
Hlavní autori:	Zhan, T, Rindtorff, N, Boutros, M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.03.2017 Nature Publishing Group
Predmet:	631/67 631/67/68 631/80/86 Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis beta Catenin - metabolism Cancer Carcinogenesis Cell Biology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular signal transduction Genetic aspects Health aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Molecular Targeted Therapy Mutation Neoplasm Metastasis Neoplasms - drug therapy Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oncogenes Oncology Protein Binding Protein expression Review Signal transduction Tumor Escape - immunology Tumorigenesis Wnt Proteins - metabolism Wnt Signaling Pathway - drug effects
ISSN:	0950-9232, 1476-5594, 1476-5594
On-line prístup:	Získať plný text
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Abstract	Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
AbstractList	Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches. Oncogene (2017) 36, 1461-1473; doi: 10.1038/onc.2016.304; published online 12 September 2016 Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches. Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches. Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current ndings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
Audience	Academic
Author	Boutros, M Zhan, T Rindtorff, N
Author_xml	– sequence: 1 givenname: T surname: Zhan fullname: Zhan, T organization: Division Signaling and Functional Genomics, Department Cell and Molecular Biology, German Cancer Research Center (DKFZ), Heidelberg University, Faculty of Medicine Mannheim, Department of Internal Medicine II, Heidelberg University, Medical Faculty Mannheim – sequence: 2 givenname: N surname: Rindtorff fullname: Rindtorff, N organization: Division Signaling and Functional Genomics, Department Cell and Molecular Biology, German Cancer Research Center (DKFZ), Heidelberg University, Faculty of Medicine Mannheim – sequence: 3 givenname: M orcidid: 0000-0002-9458-817X surname: Boutros fullname: Boutros, M email: m.boutros@dkfz.de organization: Division Signaling and Functional Genomics, Department Cell and Molecular Biology, German Cancer Research Center (DKFZ), Heidelberg University, Faculty of Medicine Mannheim, German Cancer Consortium (DKTK)
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27617575$$D View this record in MEDLINE/PubMed
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PublicationPlace_xml	– name: London – name: England – name: New York
PublicationTitle	Oncogene
PublicationTitleAbbrev	Oncogene
PublicationTitleAlternate	Oncogene
PublicationYear	2017
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
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Snippet	Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in...
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SubjectTerms	631/67 631/67/68 631/80/86 Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis beta Catenin - metabolism Cancer Carcinogenesis Cell Biology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular signal transduction Genetic aspects Health aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Molecular Targeted Therapy Mutation Neoplasm Metastasis Neoplasms - drug therapy Neoplasms - etiology Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Oncogenes Oncology Protein Binding Protein expression Review Signal transduction Tumor Escape - immunology Tumorigenesis Wnt Proteins - metabolism Wnt Signaling Pathway - drug effects
Title	Wnt signaling in cancer
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