Kinetic Analysis of Amyloid Protofibril Dissociation and Volumetric Properties of the Transition State

We present here the first detailed kinetic analysis of the dissociation reaction of amyloid protofibrils by utilizing pressure as an accelerator of the reaction. The experiment is carried out on an excessively diluted typical protofibril solution formed from an intrinsically denatured disulfide-defi...

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Bibliographic Details
Published in:	Biophysical journal Vol. 92; no. 1; pp. 323 - 329
Main Authors:	Abdul Latif, Abdul Raziq, Kono, Ryohei, Tachibana, Hideki, Akasaka, Kazuyuki
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2007 Biophysical Society
Subjects:	Amyloid beta-Peptides - chemistry Animals Biophysics - methods Cell Biophysics Chickens Disulfides - chemistry Fibers Fluorescence Hydration Kinetics Microscopy, Atomic Force Microscopy, Fluorescence Molecules Muramidase - chemistry Peptide Fragments Pressure Protein Denaturation Proteins Thermodynamics Time Factors
ISSN:	0006-3495, 1542-0086
Online Access:	Get full text
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