A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan...

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Veröffentlicht in:	Cancer cell Jg. 24; H. 2; S. 229
Hauptverfasser:	Masiero, Massimo, Simões, Filipa Costa, Han, Hee Dong, Snell, Cameron, Peterkin, Tessa, Bridges, Esther, Mangala, Lingegowda S, Wu, Sherry Yen-Yao, Pradeep, Sunila, Li, Demin, Han, Cheng, Dalton, Heather, Lopez-Berestein, Gabriel, Tuynman, Jurriaan B, Mortensen, Neil, Li, Ji-Liang, Patient, Roger, Sood, Anil K, Banham, Alison H, Harris, Adrian L, Buffa, Francesca M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.08.2013
Schlagworte:	Animals Cell Growth Processes - physiology Endothelial Cells - metabolism Endothelial Cells - pathology Female Genetic Predisposition to Disease HCT116 Cells Humans Mice Mice, Nude Neoplasms - blood supply Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction
ISSN:	1878-3686, 1878-3686
Online-Zugang:	Weitere Angaben
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