The earliest thymic progenitors for T cells possess myeloid lineage potential

Redrawing the blood lines In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors, and myeloid cells (including granulocytes and macrophages, found in bone marrow and spinal cord) from progenitors committed to the myeloid lin...

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Veröffentlicht in:	Nature Jg. 452; H. 7188; S. 764 - 767
Hauptverfasser:	Bell, J. Jeremiah, Bhandoola, Avinash
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 10.04.2008 Nature Publishing Nature Publishing Group
Schlagworte:	Animals Biological and medical sciences Blood Cell differentiation, maturation, development, hematopoiesis Cell Lineage Cell physiology Cells, Cultured Cellular biology Coculture Techniques Dendritic Cells - cytology Female Fundamental and applied biological sciences. Psychology Granulocytes - cytology Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humanities and Social Sciences Immunology letter Macrophages - cytology Mice Models, Biological Molecular and cellular biology multidisciplinary Myeloid Cells - cytology Myeloid Cells - metabolism Rodents Science Science (multidisciplinary) Stromal Cells - cytology T-Lymphocytes - cytology T-Lymphocytes - metabolism Thymus Gland - cytology Lymphoid cell Hematopoiesis Myeloid cell T-Lymphocyte Progenitor cell
ISSN:	0028-0836, 1476-4687, 1476-4687, 1476-4679
Online-Zugang:	Volltext
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Abstract	Redrawing the blood lines In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors, and myeloid cells (including granulocytes and macrophages, found in bone marrow and spinal cord) from progenitors committed to the myeloid lineage. Two papers in this issue report evidence that contradicts this. Rather, they find a single type of progenitor in adult thymus with both T and myeloid potential. T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but still produces macrophages and cells with T, NK (natural killer) and dendritic cell potential. These results support a model for haematopoiesis where the progenitor cell at the branch point of T and B cell lineages retains macrophage potential. One of two papers that show there is a single type of progenitor within the adult thymus that possesses both T and myeloid potential. It is shown that T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but can still produce macrophages as well as cells with T, NK and dendritic cell potential. These papers therefore argue against the classical dichotomy model in which T cells are derived from common lymphoid progenitors, and support a model for adult hematopoeisis where the progenitor cell at the branch point of the T and B cell lineages retains macrophage potential. There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential 1 , suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid- 2 . Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered.
AbstractList	There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential1, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-2. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered. [PUBLICATION ABSTRACT] There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered.There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered. Redrawing the blood lines In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors, and myeloid cells (including granulocytes and macrophages, found in bone marrow and spinal cord) from progenitors committed to the myeloid lineage. Two papers in this issue report evidence that contradicts this. Rather, they find a single type of progenitor in adult thymus with both T and myeloid potential. T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but still produces macrophages and cells with T, NK (natural killer) and dendritic cell potential. These results support a model for haematopoiesis where the progenitor cell at the branch point of T and B cell lineages retains macrophage potential. One of two papers that show there is a single type of progenitor within the adult thymus that possesses both T and myeloid potential. It is shown that T cells are produced by an early population in the thymus that has lost the ability to produce B cells, but can still produce macrophages as well as cells with T, NK and dendritic cell potential. These papers therefore argue against the classical dichotomy model in which T cells are derived from common lymphoid progenitors, and support a model for adult hematopoeisis where the progenitor cell at the branch point of the T and B cell lineages retains macrophage potential. There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential 1 , suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid- 2 . Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered. There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of thymus-colonizing progenitors is unknown. One approach to resolving this question is to determine the lineage potentials of the earliest thymic progenitors (ETPs). Previous work has shown that ETPs possess T and natural killer lymphoid potentials, and rare subsets of ETPs also possess B lymphoid potential, suggesting an origin from lymphoid-restricted progenitor cells. However, whether ETPs also possess myeloid potential is unknown. Here we show that nearly all ETPs in adult mice possess both T and myeloid potential in clonal assays. The existence of progenitors possessing T and myeloid potential within the thymus is incompatible with the current dominant model of haematopoiesis, in which T cells are proposed to arise from lymphoid-. Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered.
Audience	Academic
Author	Bell, J. Jeremiah Bhandoola, Avinash
Author_xml	– sequence: 1 givenname: J. Jeremiah surname: Bell fullname: Bell, J. Jeremiah organization: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA – sequence: 2 givenname: Avinash surname: Bhandoola fullname: Bhandoola, Avinash email: bhandooa@mail.med.upenn.edu organization: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20223659$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18401411$$D View this record in MEDLINE/PubMed
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Snippet	Redrawing the blood lines In the current dominant model of haematopoiesis, T cells are thought to arise from lymphoid-restricted common lymphoid progenitors,... There exists controversy over the nature of haematopoietic progenitors of T cells. Most T cells develop in the thymus, but the lineage potential of...
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SubjectTerms	Animals Biological and medical sciences Blood Cell differentiation, maturation, development, hematopoiesis Cell Lineage Cell physiology Cells, Cultured Cellular biology Coculture Techniques Dendritic Cells - cytology Female Fundamental and applied biological sciences. Psychology Granulocytes - cytology Hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humanities and Social Sciences Immunology letter Macrophages - cytology Mice Models, Biological Molecular and cellular biology multidisciplinary Myeloid Cells - cytology Myeloid Cells - metabolism Rodents Science Science (multidisciplinary) Stromal Cells - cytology T-Lymphocytes - cytology T-Lymphocytes - metabolism Thymus Gland - cytology
Title	The earliest thymic progenitors for T cells possess myeloid lineage potential
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