Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans

Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic adverse events associated with NFT exposure, there is still limited understanding of the interplay between NFT exposure, its disposition, and the...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Pharmaceutics Ročník 15; číslo 9; s. 2199
Hlavní autoři:	Sharma, Raju Prasad, Burgers, Elsje J., Beltman, Joost B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basel MDPI AG 25.08.2023 MDPI
Témata:	Antibiotics Drug dosages drug-induced liver injury Health aspects Liver Medical research Medicine, Experimental Nitrofurantoin Normal distribution Pharmacokinetics Physiological aspects physiologically based pharmacokinetic model Physiology Plasma Rabbits renal insufficiency Simulation methods Urinary tract diseases Urinary tract infections Urine Urogenital system Timor-Leste
ISSN:	1999-4923, 1999-4923
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!