Transfection of Kasumi-1 cells with a new type of polymer carriers loaded with miR-155 and antago-miR-155
Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stabili...
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| Vydané v: | Cancer gene therapy Ročník 20; číslo 4; s. 237 - 241 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
New York
Nature Publishing Group US
01.04.2013
Nature Publishing Group |
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| ISSN: | 0929-1903, 1476-5500, 1476-5500 |
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| Abstract | Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation.
In vivo
delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches. |
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| AbstractList | Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches. Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches.Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches. Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches. Cancer Gene Therapy (2013) 20, 237-241; doi: 10.1038/cgt.2013.11; published online 29 March 2013 Keywords: Kasumi-1; miR-155; platelets; polymer carriers; transfection Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches. |
| Audience | Academic |
| Author | Shtilman, M I Klimenko, O V |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23538486$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1134_S1022795415050026 crossref_primary_10_1016_j_fertnstert_2013_10_042 crossref_primary_10_1016_j_bbrc_2018_07_032 crossref_primary_10_1007_s00289_021_03936_y crossref_primary_10_1007_s12668_023_01258_z crossref_primary_10_1016_j_bbcan_2020_188491 crossref_primary_10_1038_s41388_018_0571_y crossref_primary_10_1007_s12668_022_00977_z crossref_primary_10_1007_s11172_016_1558_x crossref_primary_10_1016_j_mencom_2018_01_024 |
| Cites_doi | 10.1038/icb.2011.74 10.1021/bi200851d 10.1016/0005-2736(94)90025-6 10.1158/0008-5472.CAN-11-1035 10.1002/path.2806 10.1177/2040620711410772 10.1039/c2mb25175b 10.1182/blood-2011-01-292011 10.1101/gad.1399906 10.1182/blood-2010-06-292920 10.1038/nmeth1083 10.1101/gr.098046.109 10.1093/hmg/ddm056 10.1182/blood-2010-09-191312 10.1186/1756-8722-5-26 10.1038/nature04303 10.1038/leu.2011.221 10.1016/j.leukres.2009.04.039 10.1002/stem.623 10.1073/pnas.0808266105 10.1073/pnas.0902636106 10.1182/blood-2011-03-331371 10.1084/jem.20072108 10.1155/2011/501464 10.1182/blood.V94.10.3366.422k35_3366_3380 |
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| Title | Transfection of Kasumi-1 cells with a new type of polymer carriers loaded with miR-155 and antago-miR-155 |
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