In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients

Background In vivo, non‐invasive optical coherence tomography (OCT) permits high‐resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies. Purpose To evaluate the clinical capability of non‐invasive in vivo OCT for diagn...

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Published in:Lasers in surgery and medicine Vol. 41; no. 5; pp. 353 - 357
Main Authors: Wilder-Smith, Petra, Lee, Kenneth, Guo, Shuguang, Zhang, Jun, Osann, Kathryn, Chen, Zhongping, Messadi, Diana
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2009
Subjects:
Biopsy
Data processing
Dysplasia
Humans
imaging
Lasers
Malignancy
Mapping
Mouth - pathology
Mouth Neoplasms - pathology
non-invasive diagnosis
Observer Variation
oral dysplasia
squamous cell carcinoma
Tomography
Tomography, Optical Coherence - statistics & numerical data
ISSN:0196-8092, 1096-9101, 1096-9101
Online Access:Get full text
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Summary:Background In vivo, non‐invasive optical coherence tomography (OCT) permits high‐resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies. Purpose To evaluate the clinical capability of non‐invasive in vivo OCT for diagnosing oral dysplasia and malignancy. Experimental Design In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blinded, pre‐standardized investigators separately diagnosed each lesion based on (1) OCT and (2) histopathology. Results Intra‐ and inter‐observer agreement between diagnoses based on histopathology and imaging data was excellent, with κ values between 0.844 and 0.896. Sensitivity and specificity were also very good. Conclusions These data demonstrate the excellent capability of in vivo OCT for detecting and diagnosing oral premalignancy and malignancy in human subjects. Lasers Surg. Med. 41:353–357, 2009. © 2009 Wiley‐Liss, Inc.
Bibliography:NIH - No. EB-00293; No. CA91717
NSF - No. BES-86924
istex:B2755295E553ECC7EFD75DDB1D3E121FA0D8C5A9
ArticleID:LSM20773
DOE - No. DE903-91ER; No. 61227
AFOSR - No. F49620-00-1-0371; No. FA9550-04-1-0101
CA TRDRP - No. 14IT-0097
ark:/67375/WNG-T3QDXVBZ-M
NIH - No. EB-00293; No. NCI-91717; No. RR-01192; No. EB0002SS; No. EB002494; No. AR47551
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ISSN:0196-8092
1096-9101
1096-9101
DOI:10.1002/lsm.20773