Outcome measures in multimodal rectal cancer trials

There is a large variability regarding the definition and choice of primary endpoints in phase 2 and phase 3 multimodal rectal cancer trials, resulting in inconsistency and difficulty of data interpretation. Also, surrogate properties of early and intermediate endpoints have not been systematically...

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Bibliographic Details
Published in:	The lancet oncology Vol. 21; no. 5; pp. e252 - e264
Main Authors:	Fokas, Emmanouil, Glynne-Jones, Robert, Appelt, Ane, Beets-Tan, Regina, Beets, Geerard, Haustermans, Karin, Marijnen, Corrie, Minsky, Bruce D, Ludmir, Ethan, Quirke, Phil, Sebag-Montefiore, David, Garcia-Aguilar, Julio, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Buyse, Marc, Rödel, Claus
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.05.2020 Elsevier Limited
Subjects:	Cancer Cancer therapies Chemotherapy Clinical decision making Clinical trials Colorectal cancer Decision making Hematology, Oncology, and Palliative Medicine Lymphatic system Medical prognosis Metastases Metastasis Patients Preservation Radiation therapy Rectum Response rates Surgery
ISSN:	1470-2045, 1474-5488, 1474-5488
Online Access:	Get full text
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