Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis

Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling mechanisms in the heart is lacking. Here, we report an important novel crosstalk between cardiomyocytes and fibroblasts mediated by...

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Vydané v:	Molecular therapy. Nucleic acids Ročník 18; s. 363 - 374
Hlavní autori:	Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan, Thum, Thomas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 06.12.2019 Elsevier Limited American Society of Gene & Cell Therapy Elsevier
Predmet:	Cardiomyocytes Cardiovascular diseases Cell cycle Cell migration Experiments extracellular vesicles Fibroblasts Fibrosis Gene expression Heart Hypoxia Ischemia lncRNA MicroRNAs Microscopy Myocardial infarction Nanoparticles Neat1 Ostomy p53 Protein Ribonucleic acid RNA Studies Therapeutic applications Transcription Translation Vesicles Germany hypoxia lncRNA extracellular vesicles Neat1 myocardial infarction
ISSN:	2162-2531, 2162-2531
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