De novo protein design enables the precise induction of RSV-neutralizing antibodies

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines...

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Vydáno v:	IDEAS Working Paper Series from RePEc Ročník 368; číslo 6492
Hlavní autoři:	Sesterhenn, Fabian, Yang, Che, Bonet, Jaume, Cramer, Johannes T, Wen, Xiaolin, Wang, Yimeng, Chiang, Chi-I, Abriata, Luciano A, Kucharska, Iga, Castoro, Giacomo, Vollers, Sabrina S, Galloux, Marie, Dheilly, Elie, Rosset, Stéphane, Corthésy, Patricia, Georgeon, Sandrine, Villard, Mélanie, Richard, Charles-Adrien, Descamps, Delphyne, Delgado, Teresa, Oricchio, Elisa, Rameix-Welti, Marie-Anne, Más, Vicente, Ervin, Sean, Eléouët, Jean-François, Riffault, Sabine, Bates, John T, Julien, Jean-Philippe, Li, Yuxing, Jardetzky, Theodore, Krey, Thomas, Correia, Bruno E
Médium:	Journal Article Paper
Jazyk:	angličtina
Vydáno:	United States Federal Reserve Bank of St. Louis 15.05.2020
Témata:	Amino Acid Motifs Antibodies, Neutralizing - biosynthesis Computational Biology - methods Humans Immunodominant Epitopes - chemistry Immunodominant Epitopes - immunology Protein Conformation Protein Engineering - methods Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - immunology Respiratory Syncytial Virus Vaccines - chemistry Respiratory Syncytial Virus Vaccines - immunology Respiratory Syncytial Virus, Human - immunology Single-Domain Antibodies - chemistry Single-Domain Antibodies - immunology Vaccines
ISSN:	1095-9203, 1095-9203
On-line přístup:	Získat plný text
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