Targeting tumor–stromal interactions in bone metastasis

Bone metastasis is a frequent occurrence in late stage solid tumors, including breast cancers, prostate or lung. However, the causes for this proclivity have only recently been elucidated. Significant progress has been made in the past decade toward understanding the molecular underpinnings of bone...

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Bibliographic Details
Published in:	Pharmacology & therapeutics (Oxford) Vol. 141; no. 2; pp. 222 - 233
Main Authors:	Esposito, Mark, Kang, Yibin
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 01.02.2014
Subjects:	Animals Biological and medical sciences Bone Neoplasms - metabolism Bone Neoplasms - secondary Bone Remodeling Diseases of the osteoarticular system Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - metabolism Neoplasms - pathology Stromal Cells - metabolism Tumors Tumors of striated muscle and skeleton Host tumor relation Metastatic niche Targeting Tumor-stromal interactions Diseases of the osteoarticular system Osteoclast inhibitors Osteoclast Immune surveillance Malignant tumor Tumor dormancy Osteoarticular system Dormancy Immunological surveillance Target Bone metastasis Advanced stage Inhibitor Bone Cancer Tumor–stromal interactions mesenchymal stem cell hematopoietic stem cell T(reg) regulatory T cell DTC circulating tumor cell disseminated tumor cell natural killer CTC HSC MSC NK dendritic cell DC
ISSN:	0163-7258, 1879-016X, 1879-016X
Online Access:	Get full text
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