Design Features and Mutual Compatibility Studies of the Time-of-Flight PET Capable GE SIGNA PET/MR System

A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into...

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Published in:	IEEE transactions on medical imaging Vol. 35; no. 8; pp. 1907 - 1914
Main Authors:	Levin, Craig S., Maramraju, Sri Harsha, Khalighi, Mohammad Mehdi, Deller, Timothy W., Delso, Gaspar, Jansen, Floris
Format:	Journal Article
Language:	English
Published:	United States IEEE 01.08.2016 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Acquisitions Acquisitions & mergers Detectors Energy resolution Homogeneity Humans Image quality Magnetic Resonance Imaging Marketing Patients Phantoms, Imaging Positron emission Positron emission tomography Radio frequency scanner performance Sensors Simultaneous PET/MR SiPMs Temperature measurement Time-of-Flight PET Timing Tomography
ISSN:	0278-0062, 1558-254X, 1558-254X
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Abstract	A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into an existing 3T MR system resulting in a (patient) bore opening of 60 cm diameter, with a 25 cm axial FOV. PET performance was evaluated both on the standalone PET ring and on the same detector integrated into the MR system, to assess the level of mutual interference between both subsystems. In both configurations we obtained detector performance data. PET detector performance was not significantly affected by integration into the MR system. The global energy resolution was within 2% (10.3% versus 10.5%), and the system coincidence time resolution showed a maximum change of <; 3% (385 ps versus 394 ps) when measured outside MR and during simultaneous PET/MRI acquisitions, respectively. To evaluate PET image quality and resolution, the NEMA IQ phantom was acquired with MR idle and with MR active. Impact of PET on MR IQ was assessed by comparing SNR with PET acquisition on and off. B0 and B1 homogeneities were acquired before and after the integration of the PET ring inside the magnet. In vivo brain and whole body head-to-thighs data were acquired to demonstrate clinical image quality.
AbstractList	A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into an existing 3T MR system resulting in a (patient) bore opening of 60 cm diameter, with a 25 cm axial FOV. PET performance was evaluated both on the standalone PET ring and on the same detector integrated into the MR system, to assess the level of mutual interference between both subsystems. In both configurations we obtained detector performance data. PET detector performance was not significantly affected by integration into the MR system. The global energy resolution was within 2% (10.3% versus 10.5%), and the system coincidence time resolution showed a maximum change of < 3% (385 ps versus 394 ps) when measured outside MR and during simultaneous PET/MRI acquisitions, respectively. To evaluate PET image quality and resolution, the NEMA IQ phantom was acquired with MR idle and with MR active. Impact of PET on MR IQ was assessed by comparing SNR with PET acquisition on and off. B0 and B1 homogeneities were acquired before and after the integration of the PET ring inside the magnet. In vivo brain and whole body head-to-thighs data were acquired to demonstrate clinical image quality. A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into an existing 3T MR system resulting in a (patient) bore opening of 60 cm diameter, with a 25 cm axial FOV. PET performance was evaluated both on the standalone PET ring and on the same detector integrated into the MR system, to assess the level of mutual interference between both subsystems. In both configurations we obtained detector performance data. PET detector performance was not significantly affected by integration into the MR system. The global energy resolution was within 2% (10.3% versus 10.5%), and the system coincidence time resolution showed a maximum change of < 3% (385 ps versus 394 ps) when measured outside MR and during simultaneous PET/MRI acquisitions, respectively. To evaluate PET image quality and resolution, the NEMA IQ phantom was acquired with MR idle and with MR active. Impact of PET on MR IQ was assessed by comparing SNR with PET acquisition on and off. B0 and B1 homogeneities were acquired before and after the integration of the PET ring inside the magnet. In vivo brain and whole body head-to-thighs data were acquired to demonstrate clinical image quality.A recent entry into the rapidly evolving field of integrated PET/MR scanners is presented in this paper: a whole body hybrid PET/MR system (SIGNA PET/MR, GE Healthcare) capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data. The PET ring was integrated into an existing 3T MR system resulting in a (patient) bore opening of 60 cm diameter, with a 25 cm axial FOV. PET performance was evaluated both on the standalone PET ring and on the same detector integrated into the MR system, to assess the level of mutual interference between both subsystems. In both configurations we obtained detector performance data. PET detector performance was not significantly affected by integration into the MR system. The global energy resolution was within 2% (10.3% versus 10.5%), and the system coincidence time resolution showed a maximum change of < 3% (385 ps versus 394 ps) when measured outside MR and during simultaneous PET/MRI acquisitions, respectively. To evaluate PET image quality and resolution, the NEMA IQ phantom was acquired with MR idle and with MR active. Impact of PET on MR IQ was assessed by comparing SNR with PET acquisition on and off. B0 and B1 homogeneities were acquired before and after the integration of the PET ring inside the magnet. In vivo brain and whole body head-to-thighs data were acquired to demonstrate clinical image quality.
Author	Maramraju, Sri Harsha Delso, Gaspar Deller, Timothy W. Levin, Craig S. Khalighi, Mohammad Mehdi Jansen, Floris
Author_xml	– sequence: 1 givenname: Craig S. surname: Levin fullname: Levin, Craig S. email: cslevin@stanford.edu organization: Sch. of Med., Stanford Univ., Stanford, CA, USA – sequence: 2 givenname: Sri Harsha surname: Maramraju fullname: Maramraju, Sri Harsha organization: MR Eng., GE Healthcare, Waukesha, WI, USA – sequence: 3 givenname: Mohammad Mehdi surname: Khalighi fullname: Khalighi, Mohammad Mehdi organization: GE Healthcare, Menlo Park, CA, USA – sequence: 4 givenname: Timothy W. surname: Deller fullname: Deller, Timothy W. organization: MR Eng., GE Healthcare, Waukesha, WI, USA – sequence: 5 givenname: Gaspar surname: Delso fullname: Delso, Gaspar organization: Appl. Sci. Lab., GE Healthcare, Zurich, Switzerland – sequence: 6 givenname: Floris surname: Jansen fullname: Jansen, Floris organization: MR Eng., GE Healthcare, Waukesha, WI, USA
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SubjectTerms	Acquisitions Acquisitions & mergers Detectors Energy resolution Homogeneity Humans Image quality Magnetic Resonance Imaging Marketing Patients Phantoms, Imaging Positron emission Positron emission tomography Radio frequency scanner performance Sensors Simultaneous PET/MR SiPMs Temperature measurement Time-of-Flight PET Timing Tomography
Title	Design Features and Mutual Compatibility Studies of the Time-of-Flight PET Capable GE SIGNA PET/MR System
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