Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection

One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the ce...

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Bibliographic Details
Published in:	Veterinary Microbiology Vol. 97; no. 3; pp. 259 - 268
Main Authors:	Park, C.H, Matsuda, K, Sunden, Y, Ninomiya, A, Takada, A, Ito, H, Kimura, T, Ochiai, K, Kida, H, Umemura, T
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 30.12.2003 Elsevier BV Elsevier Science
Subjects:	Animals BALB/c mice Biological and medical sciences Brain Brain - pathology Brain - virology brain stem Central Nervous System Central Nervous System - pathology Central Nervous System - virology cerebrum CNS Disease Models, Animal encephalitis Female Fundamental and applied biological sciences. Psychology genome histopathology Immunohistochemistry Influenza A virus Influenza A virus - genetics Influenza A virus - isolation & purification Influenza virus Mice Mice, Inbred BALB C Microbiology Miscellaneous Orthomyxoviridae Infections Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Persistent infection pneumonia Random Allocation Reverse Transcriptase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA RNA, Viral RNA, Viral - analysis Specific Pathogen-Free Organisms spinal cord viral antigens Virology BALB/c mice CNS Influenza virus Persistent infection Microbiology Acute Rodentia Central nervous system Orthomyxoviridae Influenzavirus Infection Virus Vertebrata Influenzavirus A Mammalia Mouse Influenza A virus Viral disease Influenza A Veterinary
ISSN:	0378-1135, 1873-2542
Online Access:	Get full text
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