Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection
One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the ce...
Uložené v:
| Vydané v: | Veterinary Microbiology Ročník 97; číslo 3; s. 259 - 268 |
|---|---|
| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Amsterdam
Elsevier B.V
30.12.2003
Elsevier BV Elsevier Science |
| Predmet: | |
| ISSN: | 0378-1135, 1873-2542 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the central nervous system (CNS) of recovered mice, immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) methods were performed. Histopathologically, mild interstitial pneumonia and non-suppurative encephalomyelitis restricted to the basal part of the frontal lobe of the cerebrum, brain stem and thoracic spinal cord were observed in BALB/c mice until 40 PID. Small amounts of viral antigens were detected in the brain and spinal cord and some viral RNA segments (NA, NP, M, PA, HA, NS, PB1) were intermittently detected in the CNS until 48 PID. Immunosuppression of these mice by dexamethazone (DEX) treatment did not increase the frequency of detection of the lesions, viral antigens or genomes. These findings suggest that viral genomes of neurovirulent influenza virus persist with restricted transcriptive activity in the CNS of the mice even after clinical recovery from the infection. |
|---|---|
| AbstractList | One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the central nervous system (CNS) of recovered mice, immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) methods were performed. Histopathologically, mild interstitial pneumonia and non-suppurative encephalomyelitis restricted to the basal part of the frontal lobe of the cerebrum, brain stem and thoracic spinal cord were observed in BALB/c mice until 40 PID. Small amounts of viral antigens were detected in the brain and spinal cord and some viral RNA segments (NA, NP, M, PA, HA, NS, PB1) were intermittently detected in the CNS until 48 PID. Immunosuppression of these mice by dexamethazone (DEX) treatment did not increase the frequency of detection of the lesions, viral antigens or genomes. These findings suggest that viral genomes of neurovirulent influenza virus persist with restricted transcriptive activity in the CNS of the mice even after clinical recovery from the infection. One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the central nervous system (CNS) of recovered mice, immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) methods were performed. Histopathologically, mild interstitial pneumonia and non-suppurative encephalomyelitis restricted to the basal part of the frontal lobe of the cerebrum, brain stem and thoracic spinal cord were observed in BALB/c mice until 40 PID. Small amounts of viral antigens were detected in the brain and spinal cord and some viral RNA segments (NA, NP, M, PA, HA, NS, PB1) were intermittently detected in the CNS until 48 PID. Immunosuppression of these mice by dexamethazone (DEX) treatment did not increase the frequency of detection of the lesions, viral antigens or genomes. These findings suggest that viral genomes of neurovirulent influenza virus persist with restricted transcriptive activity in the CNS of the mice even after clinical recovery from the infection.One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16 days post-inoculation (PID) and 98 of the mice recovered from the infection. To investigate whether viral antigens and genomes persist in the central nervous system (CNS) of recovered mice, immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) methods were performed. Histopathologically, mild interstitial pneumonia and non-suppurative encephalomyelitis restricted to the basal part of the frontal lobe of the cerebrum, brain stem and thoracic spinal cord were observed in BALB/c mice until 40 PID. Small amounts of viral antigens were detected in the brain and spinal cord and some viral RNA segments (NA, NP, M, PA, HA, NS, PB1) were intermittently detected in the CNS until 48 PID. Immunosuppression of these mice by dexamethazone (DEX) treatment did not increase the frequency of detection of the lesions, viral antigens or genomes. These findings suggest that viral genomes of neurovirulent influenza virus persist with restricted transcriptive activity in the CNS of the mice even after clinical recovery from the infection. |
| Author | Umemura, T Park, C.H Kimura, T Ochiai, K Matsuda, K Ito, H Kida, H Takada, A Sunden, Y Ninomiya, A |
| Author_xml | – sequence: 1 givenname: C.H surname: Park fullname: Park, C.H organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 2 givenname: K surname: Matsuda fullname: Matsuda, K organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 3 givenname: Y surname: Sunden fullname: Sunden, Y organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 4 givenname: A surname: Ninomiya fullname: Ninomiya, A organization: Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 5 givenname: A surname: Takada fullname: Takada, A organization: Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan – sequence: 6 givenname: H surname: Ito fullname: Ito, H organization: Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Tottori, Japan – sequence: 7 givenname: T surname: Kimura fullname: Kimura, T organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 8 givenname: K surname: Ochiai fullname: Ochiai, K organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 9 givenname: H surname: Kida fullname: Kida, H organization: Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan – sequence: 10 givenname: T surname: Umemura fullname: Umemura, T email: umemura@vetmed.hokudai.ac.jp organization: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan |
| BackLink | https://cir.nii.ac.jp/crid/1871428067675610368$$DView record in CiNii http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15900834$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/14654295$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFklGPEyEUhYlZ43ZX_4ExPKjxpfUyMDDjg0mz2VWTjRqz74QyF6WZYVZgmtTE_y6TVk18qC8Q4DvnAvdckLMwBiTkKYMVAyZfb1c7zIO3qwqAl60VAHtAFqxRfFnVojojC-CqWTLG63NykdIWAEQr4RE5Z0IWoq0X5OdnjMmnjMEiHR3d-Wh6-uXjmib8OmDIifpA8zektizms4BxN06Jpn1RDbOmXAKpcRkjjWjHHcY9dXEcqLFTxqJ3_YThh6Hr2X6aHR3a7MfwmDx0pk_45Dhfkrub67ur98vbT-8-XK1vl7YWbV62db1RUNlOgbOCNYjcNRtrEGTLjWk71aFirm1Yw2vJHRpTma5zmwYrxi2_JC8Ptvdx_D5hynrwyWLfm4DlKVoxITiT6r9gBbISbV0V8NVJkCkGlQDFZUGfHdFpM2Cn76MfTNzr3z0owIsjYJI1vYsmWJ_-cnUL0HBRuDcHzsYxpYhOW5_N_I2lL77XDPQcDL3Vh2DoORjzbglGEYt_xH_8T8ueH2TB-1JuHkvAmKgakEqqWjLgsinY2wOGpYk7j1En6-dIdb4kIutu9Kfr_ALr2t9g |
| CODEN | VMICDQ |
| CitedBy_id | crossref_primary_10_1128_JVI_00743_08 crossref_primary_10_1128_JVI_00101_08 crossref_primary_10_1097_00001756_200507130_00016 crossref_primary_10_3390_cells10071836 crossref_primary_10_1128_mSphere_00270_21 |
| Cites_doi | 10.3109/13550289909029476 10.1046/j.1442-200x.2000.01202.x 10.1016/S0140-6736(82)90820-0 10.1080/13550280152058771 10.1016/S0168-1702(95)00077-1 10.1099/0022-1317-75-3-647 10.1093/jnen/60.7.663 10.1007/s007050050016 10.1002/jmv.1890070402 10.1007/s00705-001-0750-x 10.1084/jem.181.6.2161 10.1016/0022-510X(90)90220-H 10.1007/s004010050523 10.1292/jvms.59.143 10.1099/0022-1317-78-3-563 10.1080/13550280290100480 10.1084/jem.187.10.1575 10.1016/0168-1702(93)90123-5 10.1128/jvi.65.5.2340-2350.1991 10.1292/jvms.60.627 10.1128/JVI.75.9.4439-4443.2001 10.1016/0166-0934(94)90151-1 10.1016/S0387-7604(96)00063-0 |
| ContentType | Journal Article |
| Copyright | 2003 Elsevier B.V. 2004 INIST-CNRS |
| Copyright_xml | – notice: 2003 Elsevier B.V. – notice: 2004 INIST-CNRS |
| DBID | RYH AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7S9 L.6 7TK 7U9 H94 7X8 |
| DOI | 10.1016/j.vetmic.2003.10.001 |
| DatabaseName | CiNii Complete CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed AGRICOLA AGRICOLA - Academic Neurosciences Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AGRICOLA AGRICOLA - Academic AIDS and Cancer Research Abstracts Neurosciences Abstracts Virology and AIDS Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic AIDS and Cancer Research Abstracts AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Veterinary Medicine Biology |
| EISSN | 1873-2542 |
| EndPage | 268 |
| ExternalDocumentID | 14654295 15900834 10_1016_j_vetmic_2003_10_001 S0378113503003195 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 123 1B1 1RT 1~. 1~5 29Q 4.4 457 4G. 53G 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AABVA AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALCJ AALRI AAOAW AAQFI AARKO AATLK AAXUO ABBQC ABFNM ABFRF ABGRD ABJNI ABKYH ABLVK ABMAC ABMZM ABRWV ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACPRK ACRLP ADBBV ADEZE ADQTV AEBSH AEFWE AEKER AENEX AEQOU AESVU AEXOQ AFKWA AFRAH AFTJW AFXIZ AGEKW AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CBWCG CJTIS CNWQP CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FD6 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HMG HVGLF HZ~ IHE J1W KOM LCYCR LUGTX LW9 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. PQQKQ Q38 QYZTP R2- RIG ROL RPZ SAB SDF SDG SDP SES SEW SIN SNL SPCBC SSA SSH SSI SSZ SVS T5K WUQ ~G- ~KM AAHBH AATTM AAXKI AAYWO ACIEU ACLOT ACMHX ACVFH ADCNI ADSLC AEIPS AEUPX AFPUW AGWPP AIIUN AKBMS AKRWK AKYEP ANKPU EFKBS RYH ~HD 9DU AAYXX AFJKZ AIGII APXCP CITATION AGCQF AGRNS IQODW CGR CUY CVF ECM EIF NPM 7S9 L.6 7TK 7U9 H94 7X8 |
| ID | FETCH-LOGICAL-c549t-955b702cd70fc418ee3f8bcae0693aa9d7de71f98183563feaa2addfb8e213c3 |
| ISICitedReferencesCount | 6 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000187359700007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0378-1135 |
| IngestDate | Sun Sep 28 09:04:46 EDT 2025 Sat Sep 27 23:33:44 EDT 2025 Sun Sep 28 05:52:15 EDT 2025 Wed Feb 19 02:34:16 EST 2025 Mon Jul 21 09:12:42 EDT 2025 Sat Nov 29 07:24:49 EST 2025 Tue Nov 18 22:42:02 EST 2025 Mon Nov 10 09:04:56 EST 2025 Fri Feb 23 02:31:13 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | BALB/c mice CNS Influenza virus Persistent infection Microbiology Acute Rodentia Central nervous system Orthomyxoviridae Influenzavirus Infection Virus Vertebrata Influenzavirus A Mammalia Mouse Influenza A virus Viral disease Influenza A Veterinary |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c549t-955b702cd70fc418ee3f8bcae0693aa9d7de71f98183563feaa2addfb8e213c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 14654295 |
| PQID | 1710240736 |
| PQPubID | 24069 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_71443167 proquest_miscellaneous_20624952 proquest_miscellaneous_1710240736 pubmed_primary_14654295 pascalfrancis_primary_15900834 crossref_citationtrail_10_1016_j_vetmic_2003_10_001 crossref_primary_10_1016_j_vetmic_2003_10_001 nii_cinii_1871428067675610368 elsevier_sciencedirect_doi_10_1016_j_vetmic_2003_10_001 |
| PublicationCentury | 2000 |
| PublicationDate | 2003-12-30 |
| PublicationDateYYYYMMDD | 2003-12-30 |
| PublicationDate_xml | – month: 12 year: 2003 text: 2003-12-30 day: 30 |
| PublicationDecade | 2000 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: Netherlands |
| PublicationTitle | Veterinary Microbiology |
| PublicationTitleAlternate | Vet Microbiol |
| PublicationYear | 2003 |
| Publisher | Elsevier B.V Elsevier BV Elsevier Science |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier BV – name: Elsevier Science |
| References | Urabe, Tanaka, Tobita (BIB24) 1994; 49 Togashi, Matsuzono, Narita (BIB23) 2000; 42 Yamada, Yamanaka, Nakajima (BIB25) 1996; 92 Hawke, Stevenson, Freeman, Bangham (BIB6) 1998; 187 Abou-Donia, Jennings, Potter (BIB1) 1981; 7 Ravenholt, Foege (BIB14) 1982; 2 Rocha, Cox, Black, Harmon, Harrison, Kendal (BIB17) 1991; 65 Lapatschek, Marschall, Meier-Ewert (BIB9) 1995; 39 Mizuguchi (BIB11) 1997; 19 Takahashi, Yamada, Nakajima, Nakajima, Yamamoto, Okada (BIB21) 1995; 181 Mori, Diehl, Chauhan, Ljunggren, Kristensson (BIB12) 1999; 5 Minagawa, Tanaka, Toh, Mori (BIB10) 1994; 75 Reinacher, Bonin, Narayan, Scholtissek (BIB16) 1983; 49 Davis, Blisard, Kornfeld (BIB5) 1990; 97 Clavo, Maassab, Shaw (BIB4) 1993; 29 Silvano, Yoshikawa, Shimada, Otsuki, Umemura (BIB20) 1997; 59 Aronsson, Lannebo, Paucar, Brask, Kristensson, Karlsson (BIB3) 2002; 8 Shinya, Silvano, Morita, Shimada, Nakajima, Ito, Otsuki, Umemura (BIB18) 1998; 60 Aronsson, Karlsson, Ljunggren, Kristensson (BIB2) 2001; 7 Ito, Goto, Yamamoto, Tanaka, Takeuchi, Kuwayama, Kawaoka, Otsuki (BIB8) 2001; 75 Reid, McCall, Henry, Taubenberger (BIB15) 2000; 60 Tobita, Tanaka, Hayase (BIB22) 1997; 78 Howard, L.L., Gilden, D.H., 1997. Viral diseases of the central nervous system: persistent infections. In: Nathanson, N., Ahmed, R., Gonzalez-Scarano, F., Griffin, D.E., Holmes, K.V., Murphy, F.A., Robinson, H.L. (Eds.), Viral Pathogenesis. Lippincott-Raven, Philadelphia, New York, pp. 855–870. Shinya, Shimada, Ito, Otsuki, Morita, Tanaka, Takada, Kida, Umemura (BIB19) 2000; 145 Park, Ishinaka, Takada, Kida, Kimura, Ochiai, Umemura (BIB13) 2002; 147 Ravenholt (10.1016/j.vetmic.2003.10.001_BIB14) 1982; 2 Takahashi (10.1016/j.vetmic.2003.10.001_BIB21) 1995; 181 Yamada (10.1016/j.vetmic.2003.10.001_BIB25) 1996; 92 Silvano (10.1016/j.vetmic.2003.10.001_BIB20) 1997; 59 Clavo (10.1016/j.vetmic.2003.10.001_BIB4) 1993; 29 Lapatschek (10.1016/j.vetmic.2003.10.001_BIB9) 1995; 39 10.1016/j.vetmic.2003.10.001_BIB7 Rocha (10.1016/j.vetmic.2003.10.001_BIB17) 1991; 65 Aronsson (10.1016/j.vetmic.2003.10.001_BIB2) 2001; 7 Minagawa (10.1016/j.vetmic.2003.10.001_BIB10) 1994; 75 Hawke (10.1016/j.vetmic.2003.10.001_BIB6) 1998; 187 Togashi (10.1016/j.vetmic.2003.10.001_BIB23) 2000; 42 Ito (10.1016/j.vetmic.2003.10.001_BIB8) 2001; 75 Aronsson (10.1016/j.vetmic.2003.10.001_BIB3) 2002; 8 Mizuguchi (10.1016/j.vetmic.2003.10.001_BIB11) 1997; 19 Reinacher (10.1016/j.vetmic.2003.10.001_BIB16) 1983; 49 Mori (10.1016/j.vetmic.2003.10.001_BIB12) 1999; 5 Davis (10.1016/j.vetmic.2003.10.001_BIB5) 1990; 97 Reid (10.1016/j.vetmic.2003.10.001_BIB15) 2000; 60 Shinya (10.1016/j.vetmic.2003.10.001_BIB18) 1998; 60 Shinya (10.1016/j.vetmic.2003.10.001_BIB19) 2000; 145 Tobita (10.1016/j.vetmic.2003.10.001_BIB22) 1997; 78 Urabe (10.1016/j.vetmic.2003.10.001_BIB24) 1994; 49 Abou-Donia (10.1016/j.vetmic.2003.10.001_BIB1) 1981; 7 Park (10.1016/j.vetmic.2003.10.001_BIB13) 2002; 147 |
| References_xml | – volume: 187 start-page: 1575 year: 1998 end-page: 1582 ident: BIB6 article-title: Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system publication-title: J. Exp. Med. – volume: 7 start-page: 117 year: 2001 end-page: 124 ident: BIB2 article-title: Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice publication-title: J. Neurovirol. – volume: 60 start-page: 627 year: 1998 end-page: 629 ident: BIB18 article-title: Encephalitis in mice inoculated intranasally with an influenza virus strain originated from a water bird publication-title: J. Vet. Med. Sci. – volume: 8 start-page: 353 year: 2002 end-page: 357 ident: BIB3 article-title: Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy publication-title: J. Neurovirol. – volume: 5 start-page: 355 year: 1999 end-page: 562 ident: BIB12 article-title: Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice publication-title: J. Neurovirol. – volume: 49 start-page: 361 year: 1994 end-page: 366 ident: BIB24 article-title: Use of competitive PCR to estimate the level of NS gene persisting in MDCK cells which survived productive replication of a mutant of influenza virus A/WSN publication-title: J. Virol. Meth. – volume: 49 start-page: 686 year: 1983 end-page: 692 ident: BIB16 article-title: Pathogenesis of neurovirulent influenza A virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells publication-title: Lab. Invest. – volume: 92 start-page: 306 year: 1996 end-page: 311 ident: BIB25 article-title: Immunohistochemistry of a cytoplasmic dynein (MAP 1C)-like molecule in rodent and human brain tissue: an example of molecular mimicry between cytoplasmic dynein and influenza A virus publication-title: Acta Neuropathol. – reference: Howard, L.L., Gilden, D.H., 1997. Viral diseases of the central nervous system: persistent infections. In: Nathanson, N., Ahmed, R., Gonzalez-Scarano, F., Griffin, D.E., Holmes, K.V., Murphy, F.A., Robinson, H.L. (Eds.), Viral Pathogenesis. Lippincott-Raven, Philadelphia, New York, pp. 855–870. – volume: 97 start-page: 221 year: 1990 end-page: 231 ident: BIB5 article-title: The influenza B virus mouse model of Reye’s syndrome: clinical, virologic and morphologic studies of the encephalopathy publication-title: J. Neurol. Sci. – volume: 2 start-page: 860 year: 1982 end-page: 864 ident: BIB14 article-title: 1918 influenza, encephalitis lethargica, parkinsonism publication-title: Lancet – volume: 147 start-page: 1425 year: 2002 end-page: 1436 ident: BIB13 article-title: The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice publication-title: Arch. Virol. – volume: 59 start-page: 143 year: 1997 end-page: 148 ident: BIB20 article-title: Enhanced neuropathogenicity of avian influenza A virus by passages through air sac and brain of chicks publication-title: J. Vet. Med. Sci. – volume: 7 start-page: 251 year: 1981 end-page: 262 ident: BIB1 article-title: The spread and persistence of influenza viruses in normal and cyclophosphamide-treated mice publication-title: J. Med. Virol. – volume: 181 start-page: 2161 year: 1995 end-page: 2169 ident: BIB21 article-title: The substantia nigra is a major target for neurovirulent influenza A virus publication-title: J. Exp. Med. – volume: 29 start-page: 21 year: 1993 end-page: 31 ident: BIB4 article-title: A persistent infection in MDCK cells by an influenza type B virus publication-title: Virus Res. – volume: 19 start-page: 81 year: 1997 end-page: 92 ident: BIB11 article-title: Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan publication-title: Brain Dev. – volume: 75 start-page: 4439 year: 2001 end-page: 4443 ident: BIB8 article-title: Generation of a highly pathogenic avian influenza A virus from an avirulent field isolate by passaging in chickens publication-title: J. Virol. – volume: 78 start-page: 563 year: 1997 end-page: 566 ident: BIB22 article-title: Spontaneous excretion of virus from MDCK cells persistently infected with influenza virus A/PR/8/34 publication-title: J. Gen. Virol. – volume: 42 start-page: 192 year: 2000 end-page: 196 ident: BIB23 article-title: Epidemiology of influenza-associated encephalitis-encephalopathy in Hokkaido, the northernmost island of Japan publication-title: Pediatr. Int. – volume: 145 start-page: 187 year: 2000 end-page: 195 ident: BIB19 article-title: Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve publication-title: Arch. Virol. – volume: 60 start-page: 663 year: 2000 end-page: 670 ident: BIB15 article-title: Experimenting on the past: the enigma of von Economo’s encephalitis lethargica publication-title: J. Neuropathol. Exp. Neurol. – volume: 75 start-page: 647 year: 1994 end-page: 650 ident: BIB10 article-title: Detection of herpes simplex virus type 1-encoded RNA by polymerase chain reaction: different pattern of viral RNA detection in latently infected murine trigeminal ganglia following in vitro or in vivo reactivation publication-title: J. Gen. Virol. – volume: 39 start-page: 47 year: 1995 end-page: 54 ident: BIB9 article-title: The persistent variant of influenza C virus carries one characteristic point mutation in RNA segment 1 publication-title: Virus Res. – volume: 65 start-page: 2340 year: 1991 end-page: 2350 ident: BIB17 article-title: Antigenic and genetic variation in influenza A (H1N1) virus isolates recovered from a persistently infected immunodeficient child publication-title: J. Virol. – volume: 5 start-page: 355 year: 1999 ident: 10.1016/j.vetmic.2003.10.001_BIB12 article-title: Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice publication-title: J. Neurovirol. doi: 10.3109/13550289909029476 – volume: 42 start-page: 192 year: 2000 ident: 10.1016/j.vetmic.2003.10.001_BIB23 article-title: Epidemiology of influenza-associated encephalitis-encephalopathy in Hokkaido, the northernmost island of Japan publication-title: Pediatr. Int. doi: 10.1046/j.1442-200x.2000.01202.x – volume: 2 start-page: 860 year: 1982 ident: 10.1016/j.vetmic.2003.10.001_BIB14 article-title: 1918 influenza, encephalitis lethargica, parkinsonism publication-title: Lancet doi: 10.1016/S0140-6736(82)90820-0 – volume: 7 start-page: 117 year: 2001 ident: 10.1016/j.vetmic.2003.10.001_BIB2 article-title: Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice publication-title: J. Neurovirol. doi: 10.1080/13550280152058771 – volume: 39 start-page: 47 year: 1995 ident: 10.1016/j.vetmic.2003.10.001_BIB9 article-title: The persistent variant of influenza C virus carries one characteristic point mutation in RNA segment 1 publication-title: Virus Res. doi: 10.1016/S0168-1702(95)00077-1 – volume: 75 start-page: 647 year: 1994 ident: 10.1016/j.vetmic.2003.10.001_BIB10 article-title: Detection of herpes simplex virus type 1-encoded RNA by polymerase chain reaction: different pattern of viral RNA detection in latently infected murine trigeminal ganglia following in vitro or in vivo reactivation publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-75-3-647 – volume: 60 start-page: 663 year: 2000 ident: 10.1016/j.vetmic.2003.10.001_BIB15 article-title: Experimenting on the past: the enigma of von Economo’s encephalitis lethargica publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1093/jnen/60.7.663 – volume: 145 start-page: 187 year: 2000 ident: 10.1016/j.vetmic.2003.10.001_BIB19 article-title: Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve publication-title: Arch. Virol. doi: 10.1007/s007050050016 – volume: 7 start-page: 251 year: 1981 ident: 10.1016/j.vetmic.2003.10.001_BIB1 article-title: The spread and persistence of influenza viruses in normal and cyclophosphamide-treated mice publication-title: J. Med. Virol. doi: 10.1002/jmv.1890070402 – volume: 147 start-page: 1425 year: 2002 ident: 10.1016/j.vetmic.2003.10.001_BIB13 article-title: The invasion routes of neurovirulent A/Hong Kong/483/97 (H5N1) influenza virus into the central nervous system after respiratory infection in mice publication-title: Arch. Virol. doi: 10.1007/s00705-001-0750-x – volume: 181 start-page: 2161 year: 1995 ident: 10.1016/j.vetmic.2003.10.001_BIB21 article-title: The substantia nigra is a major target for neurovirulent influenza A virus publication-title: J. Exp. Med. doi: 10.1084/jem.181.6.2161 – volume: 97 start-page: 221 year: 1990 ident: 10.1016/j.vetmic.2003.10.001_BIB5 article-title: The influenza B virus mouse model of Reye’s syndrome: clinical, virologic and morphologic studies of the encephalopathy publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(90)90220-H – volume: 92 start-page: 306 year: 1996 ident: 10.1016/j.vetmic.2003.10.001_BIB25 article-title: Immunohistochemistry of a cytoplasmic dynein (MAP 1C)-like molecule in rodent and human brain tissue: an example of molecular mimicry between cytoplasmic dynein and influenza A virus publication-title: Acta Neuropathol. doi: 10.1007/s004010050523 – volume: 59 start-page: 143 year: 1997 ident: 10.1016/j.vetmic.2003.10.001_BIB20 article-title: Enhanced neuropathogenicity of avian influenza A virus by passages through air sac and brain of chicks publication-title: J. Vet. Med. Sci. doi: 10.1292/jvms.59.143 – volume: 78 start-page: 563 year: 1997 ident: 10.1016/j.vetmic.2003.10.001_BIB22 article-title: Spontaneous excretion of virus from MDCK cells persistently infected with influenza virus A/PR/8/34 publication-title: J. Gen. Virol. doi: 10.1099/0022-1317-78-3-563 – volume: 8 start-page: 353 year: 2002 ident: 10.1016/j.vetmic.2003.10.001_BIB3 article-title: Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy publication-title: J. Neurovirol. doi: 10.1080/13550280290100480 – volume: 187 start-page: 1575 year: 1998 ident: 10.1016/j.vetmic.2003.10.001_BIB6 article-title: Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system publication-title: J. Exp. Med. doi: 10.1084/jem.187.10.1575 – ident: 10.1016/j.vetmic.2003.10.001_BIB7 – volume: 29 start-page: 21 year: 1993 ident: 10.1016/j.vetmic.2003.10.001_BIB4 article-title: A persistent infection in MDCK cells by an influenza type B virus publication-title: Virus Res. doi: 10.1016/0168-1702(93)90123-5 – volume: 65 start-page: 2340 year: 1991 ident: 10.1016/j.vetmic.2003.10.001_BIB17 article-title: Antigenic and genetic variation in influenza A (H1N1) virus isolates recovered from a persistently infected immunodeficient child publication-title: J. Virol. doi: 10.1128/jvi.65.5.2340-2350.1991 – volume: 60 start-page: 627 year: 1998 ident: 10.1016/j.vetmic.2003.10.001_BIB18 article-title: Encephalitis in mice inoculated intranasally with an influenza virus strain originated from a water bird publication-title: J. Vet. Med. Sci. doi: 10.1292/jvms.60.627 – volume: 75 start-page: 4439 year: 2001 ident: 10.1016/j.vetmic.2003.10.001_BIB8 article-title: Generation of a highly pathogenic avian influenza A virus from an avirulent field isolate by passaging in chickens publication-title: J. Virol. doi: 10.1128/JVI.75.9.4439-4443.2001 – volume: 49 start-page: 361 year: 1994 ident: 10.1016/j.vetmic.2003.10.001_BIB24 article-title: Use of competitive PCR to estimate the level of NS gene persisting in MDCK cells which survived productive replication of a mutant of influenza virus A/WSN publication-title: J. Virol. Meth. doi: 10.1016/0166-0934(94)90151-1 – volume: 49 start-page: 686 year: 1983 ident: 10.1016/j.vetmic.2003.10.001_BIB16 article-title: Pathogenesis of neurovirulent influenza A virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells publication-title: Lab. Invest. – volume: 19 start-page: 81 year: 1997 ident: 10.1016/j.vetmic.2003.10.001_BIB11 article-title: Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan publication-title: Brain Dev. doi: 10.1016/S0387-7604(96)00063-0 |
| SSID | ssj0004960 ssib057766180 ssib006545069 ssib005901556 ssib006545071 ssib023895661 ssib017579908 |
| Score | 1.7217726 |
| Snippet | One-hundred thirty-seven BALB/c mice were intranasally inoculated with neurotropic avian influenza A virus (H5N3). Thirty-nine of these mice died within 16... |
| SourceID | proquest pubmed pascalfrancis crossref nii elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 259 |
| SubjectTerms | Animals BALB/c mice Biological and medical sciences Brain Brain - pathology Brain - virology brain stem Central Nervous System Central Nervous System - pathology Central Nervous System - virology cerebrum CNS Disease Models, Animal encephalitis Female Fundamental and applied biological sciences. Psychology genome histopathology Immunohistochemistry Influenza A virus Influenza A virus - genetics Influenza A virus - isolation & purification Influenza virus Mice Mice, Inbred BALB C Microbiology Miscellaneous Orthomyxoviridae Infections Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Persistent infection pneumonia Random Allocation Reverse Transcriptase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction - veterinary RNA RNA, Viral RNA, Viral - analysis Specific Pathogen-Free Organisms spinal cord viral antigens Virology |
| Title | Persistence of viral RNA segments in the central nervous system of mice after recovery from acute influenza A virus infection |
| URI | https://dx.doi.org/10.1016/j.vetmic.2003.10.001 https://cir.nii.ac.jp/crid/1871428067675610368 https://www.ncbi.nlm.nih.gov/pubmed/14654295 https://www.proquest.com/docview/1710240736 https://www.proquest.com/docview/20624952 https://www.proquest.com/docview/71443167 |
| Volume | 97 |
| WOSCitedRecordID | wos000187359700007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-2542 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0004960 issn: 0378-1135 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW6DSReEBQYAVaMxNuUKYmTOH6s0BAgViFUTX2LXMdBmba0Wj-0IvEP-NHcaztJp6kaPPASVWkSuT0n11_n3EvI-2kYCMWl8FUSSR9rWPsZi1M_LbTWEQoLjcP7_CsfjbLJRHzr9X43Xpj1Ja_r7OZGzP8r1HAOwEbr7D_A3T4UTsBnAB2OADsc_wp41LQjdvjGznDnHS3430fD44X-Yf1sTtrodJnHNYQLFMLapM5mw71CG4GpHo4TZvgLNtaHIhXKCipb2OSnhKgCj191kq56e6x7jkoba_e9qrp8T92mlVVpb_kjzuRysSrk7dVXdLnVXU9h9lDQS72R3VJss2zBTHLEYCu6MZy-hjZXSROKrVTXUa6x_7jIahOH34n4dvHh4mStl_BbTILXEyPXC7cvB4jmVwbwMDYlupKu_2tVic1Xe-Qg4omAGHkw_Hw6-dL5bIVxnbdNb6yYRi94twGYkNY9cteoZ6-uKpTjygW8kaUtpbJ7rmPGPOMn5LGbrNChJdlT0tN1nzy05Us3fdLvEKZnTqPxjPzaIiCdldQQkAIBaUNAWtUUCEgdAakjILUExHuQgNQQkDYEpEhAaghIWwLSITUEpC0Bn5Pxx9Pxh0--K_IB0SEWS18kyZQHkSp4UKo4zLRmZTZVUgepYFKKgheah6WAgSVLUlZqKSPok8tpBqGEKfaC7NezWr8kNMiE0rzAnHjTOGMwFC1EqoRSMKPHAvYeYQ0GuXIJ8LEOy2XeKB0vcgsi1mZleBZA9Ijf3jW3CWDuuZ438OZuEGsHpzkw9p47j4AN0DQ8hhnHXIiByacIzWdp5pHBLZ50zcHKvxBhPfKuIU4OnQTu_MlaA355iPOIGHrz1CNvd1wTBSnWoY92XwEtMokzPHJoWdm1wNH81c5vXpNHXRR4Q_aX1yt9RB6o9bJaXA_IHp9kA_e6_QGZNffo |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Persistence+of+viral+RNA+segments+in+the+central+nervous+system+of+mice+after+recovery+from+acute+influenza+A+virus+infection&rft.jtitle=Veterinary+microbiology&rft.au=Park%2C+C+H&rft.au=Matsuda%2C+K&rft.au=Sunden%2C+Y&rft.au=Ninomiya%2C+A&rft.date=2003-12-30&rft.issn=0378-1135&rft.volume=97&rft.issue=3-4&rft.spage=259&rft_id=info:doi/10.1016%2Fj.vetmic.2003.10.001&rft_id=info%3Apmid%2F14654295&rft.externalDocID=14654295 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-1135&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-1135&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-1135&client=summon |