Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA

The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3 (FoxP3). Through alternative splicing, the human FoxP3 gene produces four different splice variants: a full-length variant (FL) and truncated varia...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 13; no. 1; p. 77
Main Authors:	Blinova, Varvara G., Gladilina, Yulia A., Abramova, Anna A., Eliseeva, Daria D., Vtorushina, Valentina V., Shishparenok, Anastasia N., Zhdanov, Dmitry D.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29.12.2023 MDPI
Subjects:	Alternative splicing Antibodies Autoimmune diseases Cell Proliferation Cloning Dehydrogenases Exons Flow cytometry Forkhead protein Forkhead Transcription Factors - genetics FoxP3 Foxp3 protein Health aspects Humans Immunoregulation Immunotherapy Lymphocytes T Messenger RNA Multiple sclerosis Oligonucleotides Peripheral blood Phenotypes Proteins regulatory T cells RNA Precursors - genetics Software splicing-switching oligonucleotides suppressive activity T cells T-Lymphocytes, Regulatory Transcription factors Russia United States > US Germany regulatory T cells splicing-switching oligonucleotides alternative splicing FoxP3 multiple sclerosis suppressive activity
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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