Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Inhibition of protein–DNA interactions represents an attractive strategy to modulate essential cellular functions. We reported the synthesis of unique oligoamide-based foldamers that adopt single helical conformations and mimic the negatively charged phosphate moieties of B-DNA. These mimics alter t...

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Bibliographic Details
Published in:	Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 7; p. 624
Main Authors:	Corvaglia, Valentina, Ait Mohamed Amar, Imène, Garambois, Véronique, Letast, Stéphanie, Garcin, Aurélie, Gongora, Céline, Del Rio, Maguy, Denevault-Sabourin, Caroline, Joubert, Nicolas, Huc, Ivan, Pourquier, Philippe
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 28.06.2021 MDPI
Subjects:	Acids antibody-drug conjugate Antigens Biological activity Breast cancer Cancer Cytotoxicity DNA mimics Enzymes foldamer Gene expression HER2 Life Sciences Molecular weight Monoclonal antibodies Ovarian cancer Payloads Proteins trastuzumab Foldamer DNA mimics HER2 Trastuzumab Antibody-drug conjugate
ISSN:	1424-8247, 1424-8247
Online Access:	Get full text
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