Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated in many age-related diseases. Here, we invest...

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Veröffentlicht in:	eLife Jg. 12
Hauptverfasser:	Rossi, Martina, Anerillas, Carlos, Idda, Maria Laura, Munk, Rachel, Shin, Chang Hoon, Donega, Stefano, Tsitsipatis, Dimitrios, Herman, Allison B, Martindale, Jennifer L, Yang, Xiaoling, Piao, Yulan, Mazan-Mamczarz, Krystyna, Fan, Jinshui, Ferrucci, Luigi, Johnson, Peter F, De, Supriyo, Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 21.04.2023 eLife Sciences Publications, Ltd eLife Sciences Publications Ltd
Schlagworte:	Aging - genetics Analysis Animals B-Cell Activating Factor - genetics B-Cell Activating Factor - metabolism B-Cell Activating Factor - pharmacology BAFF Biological response modifiers Cell Biology Cellular Senescence - genetics Cytokines Cytokines - metabolism Developmental Biology Growth Humans Inflammation Leukemia Mice paracrine Proteases RNA SASP Secretome senescence Tumor proteins Canada senescence BAFF mouse cell biology developmental biology paracrine SASP human
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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