Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia

Airway infection with influenza virus induces local expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which has been shown to enhance inflammatory mediator responses in vitro. Because secondary pneumococcal infections occurring shortly after recovery from influenza...

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Veröffentlicht in:	The Journal of infectious diseases Jg. 193; H. 2; S. 214
Hauptverfasser:	van der Sluijs, Koenraad F, Nijhuis, Monique, Levels, Johannes H M, Florquin, Sandrine, Mellor, Andrew L, Jansen, Henk M, van der Poll, Tom, Lutter, René
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.01.2006
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - cytology Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacology Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Female Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Influenza A virus Interleukin-10 - analysis Interleukin-10 - biosynthesis Lung - immunology Lung - microbiology Mice Mice, Inbred C57BL Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - enzymology Orthomyxoviridae Infections - immunology Pneumonia, Pneumococcal - etiology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - microbiology Streptococcus pneumoniae - growth & development Streptococcus pneumoniae - immunology Survival Analysis Tryptophan - administration & dosage Tryptophan - analogs & derivatives Tryptophan - pharmacology Tumor Necrosis Factor-alpha - analysis
ISSN:	0022-1899
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