Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial

Cutaneous T-cell lymphomas are rare non-Hodgkin lymphomas with substantial morbidity and mortality in advanced disease stages. We compared the efficacy of mogamulizumab, a novel monoclonal antibody directed against C-C chemokine receptor 4, with vorinostat in patients with previously treated cutaneo...

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Vydáno v:	The lancet oncology Ročník 19; číslo 9; s. 1192 - 1204
Hlavní autoři:	Kim, Youn H, Bagot, Martine, Pinter-Brown, Lauren, Rook, Alain H, Porcu, Pierluigi, Horwitz, Steven M, Whittaker, Sean, Tokura, Yoshiki, Vermeer, Maarten, Zinzani, Pier Luigi, Sokol, Lubomir, Morris, Stephen, Kim, Ellen J, Ortiz-Romero, Pablo L, Eradat, Herbert, Scarisbrick, Julia, Tsianakas, Athanasios, Elmets, Craig, Dalle, Stephane, Fisher, David C, Halwani, Ahmad, Poligone, Brian, Greer, John, Fierro, Maria Teresa, Khot, Amit, Moskowitz, Alison J, Musiek, Amy, Shustov, Andrei, Pro, Barbara, Geskin, Larisa J, Dwyer, Karen, Moriya, Junji, Leoni, Mollie, Humphrey, Jeffrey S, Hudgens, Stacie, Grebennik, Dmitri O, Tobinai, Kensei, Duvic, Madeleine, Abhyankar, Sunil, Akilov, Oleg, Alpdogan, Onder, Beylot-Barry, Marie, Boh, Erin, Caballero, Dolores, Cowan, Richard, Dreno, Brigitte, Dummer, Reinhard, Fenske, Timothy, Foss, Francine, Fukuhara, Noriko, Giri, Pratyush, Habe, Koji, Hamada, Toshihisa, Hatake, Kiyohiko, Iida, Shinsuke, Ishikawa, Osamu, Iversen, Lars, Kiyohara, Eiji, Koga, Hiroshi, Korman, Neil, Kuss, Bryone Jean, Lamar, Zanetta, Lansigan, Frederick, Lechowicz, Mary Jo, Lerner, Adam, Magnolo, Nina, Mark, Lawrence, Miyagaki, Tomomitsu, Munoz, Javier, Nicolay, Jan Peter, Nishiwaki, Kaoru, Okamoto, Hiroyuki, Ohtsuka, Mikio, Pacheco, Theresa, Querfeld, Christiane, Rapini, Ronald Peter, Sano, Shigetoshi, Tanaka, Maiko, Tharp, Michael D., Uehara, Jiro, Wada, Hidefumi, Wells, Jillian, Wilcox, Ryan A., William, Basem, Yonekura, Kentaro
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.09.2018 Elsevier Limited
Témata:	Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic Agents, Immunological - administration & dosage Antineoplastic Agents, Immunological - adverse effects Australia Bronchopneumonia Cellulitis Chemokines Clinical trials Disease control Drug Administration Schedule Drug Resistance, Neoplasm Drugs Embolism Europe FDA approval Female Fever Fungal infections Hematology, Oncology, and Palliative Medicine Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylase Inhibitors - adverse effects Humans Immunotherapy Japan Leukemia Lymphatic system Lymphocytes T Lymphoma Lymphoma, T-Cell, Cutaneous - drug therapy Lymphoma, T-Cell, Cutaneous - mortality Lymphoma, T-Cell, Cutaneous - pathology Male Middle Aged Monoclonal antibodies Morbidity Motivation Mycosis Mycosis fungoides Mycosis Fungoides - drug therapy Mycosis Fungoides - mortality Mycosis Fungoides - pathology Neoplasm Recurrence, Local Neoplasm Staging Patients Polymyositis Product development Progression-Free Survival Renal function Sepsis Sezary Syndrome - drug therapy Sezary Syndrome - mortality Sezary Syndrome - pathology Studies T-cell lymphoma Targeted cancer therapy Time Factors Toxicity United States Vorinostat - administration & dosage Vorinostat - adverse effects Australia United States Europe Japan United States > US
ISSN:	1470-2045, 1474-5488, 1474-5488
On-line přístup:	Získat plný text
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