Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10 ) for one or more cytokines. Fifte...

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Veröffentlicht in:	American journal of human genetics Jg. 100; H. 1; S. 40
Hauptverfasser:	Ahola-Olli, Ari V, Würtz, Peter, Havulinna, Aki S, Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S, Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.01.2017
Schlagworte:	Autoimmune Diseases - genetics Colitis, Ulcerative - genetics Crohn Disease - genetics Cytokines - blood Female Genome-Wide Association Study Humans Inflammation - genetics Intercellular Signaling Peptides and Proteins - blood Male Multiple Sclerosis - genetics Quantitative Trait Loci - genetics
ISSN:	1537-6605, 1537-6605
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