EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux

The sterol-responsive nuclear receptors, liver X receptors α (LXRα, ) and β (LXRβ, ), are key determinants of cellular cholesterol homeostasis. LXRs are activated under conditions of high cellular sterol load and induce expression of the cholesterol efflux transporters and to promote efflux of exces...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 37; H. 3; S. 423 - 432
Hauptverfasser:	Nelson, Jessica Kristine, Koenis, Duco Steven, Scheij, Saskia, Cook, Emma Clare Laura, Moeton, Martina, Santos, Ana, Lobaccaro, Jean-Marc Adolphe, Baron, Silvere, Zelcer, Noam
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2017
Schlagworte:	Animals Apolipoprotein A-I - metabolism ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism Biological Transport Cell Membrane - drug effects Cell Membrane - enzymology Chlorocebus aethiops Cholesterol - metabolism COS Cells Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Gene Expression Profiling - methods Gene Expression Regulation, Enzymologic HeLa Cells Hep G2 Cells Humans Ligands Liver X Receptors - agonists Liver X Receptors - deficiency Liver X Receptors - genetics Liver X Receptors - metabolism Macrophages - drug effects Macrophages - enzymology Male Mice Mice, Inbred C57BL Mice, Knockout RAW 264.7 Cells RNA Interference Transcriptome Transfection ABCA1 nuclear receptors macrophages cholesterol efflux cholesterol metabolism LXR
ISSN:	1524-4636
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