Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

How Polycomb repressive complex 2 (PRC2) is recruited to active chromatin to mediate transcriptional silencing during lineage specification in metazoans has been unclear. New findings now show that PRC2 component PHF19, which associates with the H3K36me3 demethylase NO66, binds the active chromatin...

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Veröffentlicht in:	Nature structural & molecular biology Jg. 19; H. 12; S. 1273 - 1281
Hauptverfasser:	Brien, Gerard L, Gambero, Guillermo, O'Connell, David J, Jerman, Emilia, Turner, Siobhán A, Egan, Chris M, Dunne, Eiseart J, Jurgens, Maike C, Wynne, Kieran, Piao, Lianhua, Lohan, Amanda J, Ferguson, Neil, Shi, Xiaobing, Sinha, Krishna M, Loftus, Brendan J, Cagney, Gerard, Bracken, Adrian P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.12.2012 Nature Publishing Group
Schlagworte:	631/136/532/1360 631/337/176/2016 631/337/572 Animals Biochemistry Biological Microscopy Cell Differentiation Cellular biology Chromatin Embryology Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Gene loci Gene targeting Genetic aspects Growth Histones - metabolism Life Sciences Membrane Biology Metazoa Mice Polycomb Repressive Complex 2 - metabolism Protein binding Protein Structure Proteins Stem cells United States
ISSN:	1545-9993, 1545-9985, 1545-9985
Online-Zugang:	Volltext
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