Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis

The relation between consumption of different types of red meats and risk of type 2 diabetes (T2D) remains uncertain. We evaluated the association between unprocessed and processed red meat consumption and incident T2D in US adults. We followed 37,083 men in the Health Professionals Follow-Up Study...

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Vydáno v:The American journal of clinical nutrition Ročník 94; číslo 4; s. 1088
Hlavní autoři: Pan, An, Sun, Qi, Bernstein, Adam M, Schulze, Matthias B, Manson, JoAnn E, Willett, Walter C, Hu, Frank B
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.10.2011
Témata:
Adult
Aged
Cohort Studies
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - prevention & control
Diet - adverse effects
Female
Follow-Up Studies
Food Handling
Humans
Incidence
Male
Meat - adverse effects
Middle Aged
Prospective Studies
Reproducibility of Results
Risk
Surveys and Questionnaires
United States - epidemiology
United States
ISSN:1938-3207, 1938-3207
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Shrnutí:The relation between consumption of different types of red meats and risk of type 2 diabetes (T2D) remains uncertain. We evaluated the association between unprocessed and processed red meat consumption and incident T2D in US adults. We followed 37,083 men in the Health Professionals Follow-Up Study (1986-2006), 79,570 women in the Nurses' Health Study I (1980-2008), and 87,504 women in the Nurses' Health Study II (1991-2005). Diet was assessed by validated food-frequency questionnaires, and data were updated every 4 y. Incident T2D was confirmed by a validated supplementary questionnaire. During 4,033,322 person-years of follow-up, we documented 13,759 incident T2D cases. After adjustment for age, BMI, and other lifestyle and dietary risk factors, both unprocessed and processed red meat intakes were positively associated with T2D risk in each cohort (all P-trend <0.001). The pooled HRs (95% CIs) for a one serving/d increase in unprocessed, processed, and total red meat consumption were 1.12 (1.08, 1.16), 1.32 (1.25, 1.40), and 1.14 (1.10, 1.18), respectively. The results were confirmed by a meta-analysis (442,101 participants and 28,228 diabetes cases): the RRs (95% CIs) were 1.19 (1.04, 1.37) and 1.51 (1.25, 1.83) for 100 g unprocessed red meat/d and for 50 g processed red meat/d, respectively. We estimated that substitutions of one serving of nuts, low-fat dairy, and whole grains per day for one serving of red meat per day were associated with a 16-35% lower risk of T2D. Our results suggest that red meat consumption, particularly processed red meat, is associated with an increased risk of T2D.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1938-3207
1938-3207
DOI:10.3945/ajcn.111.018978