A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators

The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, and variable peripheral refractoriness to hormone action. Here we describe a novel leucine to valine mutation in codon 454 (L454V) of the thyro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 94; H. 1; S. 248
Hauptverfasser:	Collingwood, T N, Rajanayagam, O, Adams, M, Wagner, R, Cavaillès, V, Kalkhoven, E, Matthews, C, Nystrom, E, Stenlof, K, Lindstedt, G, Tisell, L, Fletterick, R J, Parker, M G, Chatterjee, V K
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.01.1997
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Binding Sites Dimerization DNA-Binding Proteins - metabolism Genes, Reporter Histone Acetyltransferases Humans Leucine - genetics Models, Molecular Mutation Nuclear Proteins - metabolism Nuclear Receptor Coactivator 1 Nuclear Receptor Interacting Protein 1 Protein Binding Receptors, Thyroid Hormone - genetics Recombinant Proteins - metabolism Syndrome Thyroid Hormone Resistance Syndrome - genetics Thyroid Hormones - pharmacology Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Valine - genetics
ISSN:	0027-8424
Online-Zugang:	Weitere Angaben
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