Interleukin-6 trans signalling enhances photodynamic therapy by modulating cell cycling

Photodynamic therapy (PDT) of solid tumours causes tissue damage that elicits local and systemic inflammation with major involvement of interleukin-6 (IL-6). We have previously reported that PDT-treated cells lose responsiveness to IL-6 cytokines. Therefore, it is unclear whether PDT surviving tumou...

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Veröffentlicht in:	British journal of cancer Jg. 97; H. 11; S. 1513 - 1522
Hauptverfasser:	Wei, L-H, Baumann, H, Tracy, E, Wang, Y, Hutson, A, Rose-John, S, Henderson, B W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.12.2007 Nature Publishing Group
Schlagworte:	Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research cdc25 Phosphatases - metabolism Cell cycle Cell Cycle - drug effects Cell Cycle - physiology Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chlorophyll - analogs & derivatives Chlorophyll - pharmacology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Culture Media, Conditioned - pharmacology Cyclin E - metabolism Cyclin-Dependent Kinase 2 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cytokines Dose-Response Relationship, Drug Drug Resistance Epidemiology HeLa Cells Humans Inflammation Interleukin-6 - metabolism Interleukin-6 - pharmacology Interleukin-6 - physiology Macrophages - drug effects Macrophages - metabolism Medical research Medical sciences Mice Mice, Inbred BALB C Molecular Medicine Oncology Penicillin Photochemotherapy Photodynamic therapy Receptors, Interleukin-6 - metabolism Signal Transduction - physiology STAT3 Transcription Factor - metabolism Thoracic surgery Translational Therapeutics Tumors United States > US soluble interleukin-6 receptor cell cycle photodynamic therapy interleukin-6 Interleukin 6 Signal transduction Cancerology Photodynamic therapy Cell therapy Treatment Interleukin 6 receptor Cytokine Cell cycle Soluble form
ISSN:	0007-0920, 1532-1827
Online-Zugang:	Volltext
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