Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

A genome-wide screen for genetic alterations in radiation-induced thymic lymphomas generated from p53 +/− and p53 −/− mice showed frequent loss of heterozygosity (LOH) on chromosome 6. Fine mapping of these LOH regions revealed three non-overlapping regions, one of which was refined to a 0.2 Mb inte...

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Bibliographic Details
Published in:	Oncogene Vol. 31; no. 9; pp. 1176 - 1180
Main Authors:	Mao, J-H, Wu, D, Kim, I-J, Kang, H C, Wei, G, Climent, J, Kumar, A, Pelorosso, F G, DelRosario, R, Huang, E J, Balmain, A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.03.2012 Nature Publishing Group
Subjects:	Animals Apoptosis BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - radiation effects chromosome 6 Chromosomes, Mammalian gamma Radiation Gamma rays Gamma Rays - adverse effects Gene Expression Regulation, Neoplastic Gene mapping Genetic aspects Genetics & Heredity Health aspects HIPK2 protein Human Genetics Internal Medicine Loss of Heterozygosity Lymphoma Lymphoma - genetics Lymphoma - metabolism Lymphomas Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Neoplasms, Radiation-Induced - genetics Neoplasms, Radiation-Induced - metabolism Oncology Original original-article p53 protein Peptide mapping Physiological aspects Protein Binding Protein kinase Protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Risk factors Thymus Thymus Neoplasms - genetics Thymus Neoplasms - metabolism Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors United States radiation tumorigenesis p53
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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