CRTC3 links catecholamine signalling to energy balance

The adipose-derived hormone leptin maintains energy balance in part through central nervous system-mediated increases in sympathetic outflow that enhance fat burning. Triggering of β-adrenergic receptors in adipocytes stimulates energy expenditure by cyclic AMP (cAMP)-dependent increases in lipolysi...

Full description

Saved in:

Bibliographic Details
Published in:	Nature (London) Vol. 468; no. 7326; pp. 933 - 939
Main Authors:	Song, Youngsup, Altarejos, Judith, Goodarzi, Mark O., Inoue, Hiroshi, Guo, Xiuqing, Berdeaux, Rebecca, Kim, Jeong-Ho, Goode, Jason, Igata, Motoyuki, Paz, Jose C., Hogan, Meghan F., Singh, Pankaj K., Goebel, Naomi, Vera, Lili, Miller, Nina, Cui, Jinrui, Jones, Michelle R., Consortium, CHARGE, Consortium, GIANT, Chen, Yii-Der I., Taylor, Kent D., Hsueh, Willa A., Rotter, Jerome I., Montminy, Marc
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.12.2010 Nature Publishing Group
Subjects:	631/443/319/333/1465 631/45/612/822 631/80/86/820 692/699/2743/393 Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose tissues Animals Bioenergetics Biological and medical sciences Body Temperature Catecholamines Catecholamines - metabolism Cells, Cultured Central nervous system Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors Cyclic AMP Response Element-Binding Protein - metabolism Dietary Fats - pharmacology Energy balance Energy metabolism Energy Metabolism - genetics Female Genome-Wide Association Study Health aspects Hormones Humanities and Social Sciences Humans Insulin Resistance Leptin Medical sciences Metabolic diseases Mexican Americans - genetics Mice multidisciplinary Obesity Obesity - chemically induced Obesity - genetics Obesity - metabolism Phosphorylation Properties Receptors, Adrenergic, beta - metabolism RGS Proteins - biosynthesis RGS Proteins - genetics Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transcription Factors - chemistry Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcriptional coactivators United States Obesity Leptin Knockout mouse Adipokine Catecholamine Transcription factor CREB β-Adrenergic receptor
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!