CRTC3 links catecholamine signalling to energy balance

The adipose-derived hormone leptin maintains energy balance in part through central nervous system-mediated increases in sympathetic outflow that enhance fat burning. Triggering of β-adrenergic receptors in adipocytes stimulates energy expenditure by cyclic AMP (cAMP)-dependent increases in lipolysi...

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Vydáno v:	Nature (London) Ročník 468; číslo 7326; s. 933 - 939
Hlavní autoři:	Song, Youngsup, Altarejos, Judith, Goodarzi, Mark O., Inoue, Hiroshi, Guo, Xiuqing, Berdeaux, Rebecca, Kim, Jeong-Ho, Goode, Jason, Igata, Motoyuki, Paz, Jose C., Hogan, Meghan F., Singh, Pankaj K., Goebel, Naomi, Vera, Lili, Miller, Nina, Cui, Jinrui, Jones, Michelle R., Consortium, CHARGE, Consortium, GIANT, Chen, Yii-Der I., Taylor, Kent D., Hsueh, Willa A., Rotter, Jerome I., Montminy, Marc
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 16.12.2010 Nature Publishing Group
Témata:	631/443/319/333/1465 631/45/612/822 631/80/86/820 692/699/2743/393 Adipocytes - drug effects Adipocytes - metabolism Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose tissues Animals Bioenergetics Biological and medical sciences Body Temperature Catecholamines Catecholamines - metabolism Cells, Cultured Central nervous system Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors Cyclic AMP Response Element-Binding Protein - metabolism Dietary Fats - pharmacology Energy balance Energy metabolism Energy Metabolism - genetics Female Genome-Wide Association Study Health aspects Hormones Humanities and Social Sciences Humans Insulin Resistance Leptin Medical sciences Metabolic diseases Mexican Americans - genetics Mice multidisciplinary Obesity Obesity - chemically induced Obesity - genetics Obesity - metabolism Phosphorylation Properties Receptors, Adrenergic, beta - metabolism RGS Proteins - biosynthesis RGS Proteins - genetics Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transcription Factors - chemistry Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcriptional coactivators United States Obesity Leptin Knockout mouse Adipokine Catecholamine Transcription factor CREB β-Adrenergic receptor
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line přístup:	Získat plný text
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