Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes

Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Diffe...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 23; no. 23; p. 14987
Main Authors: Ren, Yanru, Fan, Lu, Alkildani, Said, Liu, Luo, Emmert, Steffen, Najman, Stevo, Rimashevskiy, Denis, Schnettler, Reinhard, Jung, Ole, Xiong, Xin, Barbeck, Mike
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.12.2022
MDPI
Subjects:
Bacterial infections
Biocompatibility
Biocompatible Materials
Biofilms
Biological activity
Biological products
Bone Regeneration
Bones
Carbon
Collagen
Fluorine
Guided Tissue Regeneration
Guided Tissue Regeneration, Periodontal - methods
Immune response
Membranes
Membranes, Artificial
Polytetrafluoroethylene
Review
Tissue engineering
Titanium
Germany
macrophages
bioactive factor
immune response
titanium
absorbable membrane
collagen sources
vascularization
polytetrafluoroethylene (PTFE)
crosslinking
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal. This work provides a comparative summary of common barrier membranes used in GBR, focusing on recent advances in collagen membranes and their biological mechanisms. In conclusion, the review article highlights the biological and regenerative properties of currently available barrier membranes with a particular focus on bioresorbable collagen-based materials. In addition, the advantages and disadvantages of these biomaterials are highlighted, and possible improvements for future material developments are summarized.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232314987