A pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine)-decorated liposome system for protein delivery: An application for bladder cancer treatment

Stealth pH-responsive liposomes for the delivery of therapeutic proteins to the bladder epithelium were prepared using methoxy-poly(ethylene glycol)5kDa-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (mPEG5kDa-DSPE) and stearoyl-poly(ethylene glycol)-poly(methacryloyl sulfadimethoxine) copolymer (s...

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Bibliographic Details
Published in:	Journal of controlled release Vol. 238; pp. 31 - 42
Main Authors:	Vila-Caballer, Marian, Codolo, Gaia, Munari, Fabio, Malfanti, Alessio, Fassan, Matteo, Rugge, Massimo, Balasso, Anna, de Bernard, Marina, Salmaso, Stefano
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 28.09.2016
Subjects:	Animals Antineoplastic Agents - administration & dosage biopharmaceuticals bladder Bladder cancer treatment bovine serum albumin Cell Line, Tumor composite polymers confocal microscopy Delayed-Action Preparations - metabolism epithelium Epithelium - metabolism ethylene glycol Female fluorescein Fluorescein-5-isothiocyanate - administration & dosage Fluorescein-5-isothiocyanate - analogs & derivatives Hydrogen-Ion Concentration lipids Liposomes - metabolism macrophages Mice Mice, Inbred C57BL neoplasm cells pH-responsive liposomes photons Polyethylene Glycols - metabolism Polymethacrylic Acids - metabolism Protein delivery Serum Albumin, Bovine - administration & dosage soybeans spectroscopy sulfadimethoxine Sulfonamides - metabolism transmission electron microscopy Tumour targeting Urinary Bladder - metabolism urinary bladder neoplasms Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - metabolism urine zeta potential Protein delivery pH-responsive liposomes Tumour targeting Bladder cancer treatment
ISSN:	0168-3659, 1873-4995, 1873-4995
Online Access:	Get full text
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