The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject’s Individual Age, Sex, Body Mass Index and Ethnicity
Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject’s individual age, se...
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| Abstract | Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject’s individual age, sex, body mass index and ethnicity. UA-ADRCs were isolated from lipoaspirate from n = 232 subjects undergoing elective lipoplasty using the Transpose RT system (InGeneron, Inc.; Houston, TX, USA). The UA-ADRCs were assessed for the number of nucleated cells, cell viability and the number of viable nucleated cells per gram of adipose tissue harvested. Cells from n = 37 subjects were further characterized using four-channel flow cytometry. The present study shows, for the first time, that key characteristics of UA-ADRCs can be independent of the subject’s age, sex, BMI and ethnicity. This result has important implications for the general applicability of UA-ADRCs in regeneration of musculoskeletal tissue. Future studies must determine whether the independence of key characteristics of UA-ADRCs of the subject’s individual age, sex, BMI and ethnicity only applies to the system used in the present study, or also to others of the more than 25 different experimental methods and commercially available systems used to isolate UA-ADRCs from lipoaspirate that have been described in the literature. |
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| AbstractList | Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject’s individual age, sex, body mass index and ethnicity. UA-ADRCs were isolated from lipoaspirate from n = 232 subjects undergoing elective lipoplasty using the Transpose RT system (InGeneron, Inc.; Houston, TX, USA). The UA-ADRCs were assessed for the number of nucleated cells, cell viability and the number of viable nucleated cells per gram of adipose tissue harvested. Cells from n = 37 subjects were further characterized using four-channel flow cytometry. The present study shows, for the first time, that key characteristics of UA-ADRCs can be independent of the subject’s age, sex, BMI and ethnicity. This result has important implications for the general applicability of UA-ADRCs in regeneration of musculoskeletal tissue. Future studies must determine whether the independence of key characteristics of UA-ADRCs of the subject’s individual age, sex, BMI and ethnicity only applies to the system used in the present study, or also to others of the more than 25 different experimental methods and commercially available systems used to isolate UA-ADRCs from lipoaspirate that have been described in the literature. Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject's individual age, sex, body mass index and ethnicity. UA-ADRCs were isolated from lipoaspirate from = 232 subjects undergoing elective lipoplasty using the Transpose RT system (InGeneron, Inc.; Houston, TX, USA). The UA-ADRCs were assessed for the number of nucleated cells, cell viability and the number of viable nucleated cells per gram of adipose tissue harvested. Cells from = 37 subjects were further characterized using four-channel flow cytometry. The present study shows, for the first time, that key characteristics of UA-ADRCs can be independent of the subject's age, sex, BMI and ethnicity. This result has important implications for the general applicability of UA-ADRCs in regeneration of musculoskeletal tissue. Future studies must determine whether the independence of key characteristics of UA-ADRCs of the subject's individual age, sex, BMI and ethnicity only applies to the system used in the present study, or also to others of the more than 25 different experimental methods and commercially available systems used to isolate UA-ADRCs from lipoaspirate that have been described in the literature. Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject's individual age, sex, body mass index and ethnicity. UA-ADRCs were isolated from lipoaspirate from n = 232 subjects undergoing elective lipoplasty using the Transpose RT system (InGeneron, Inc.; Houston, TX, USA). The UA-ADRCs were assessed for the number of nucleated cells, cell viability and the number of viable nucleated cells per gram of adipose tissue harvested. Cells from n = 37 subjects were further characterized using four-channel flow cytometry. The present study shows, for the first time, that key characteristics of UA-ADRCs can be independent of the subject's age, sex, BMI and ethnicity. This result has important implications for the general applicability of UA-ADRCs in regeneration of musculoskeletal tissue. Future studies must determine whether the independence of key characteristics of UA-ADRCs of the subject's individual age, sex, BMI and ethnicity only applies to the system used in the present study, or also to others of the more than 25 different experimental methods and commercially available systems used to isolate UA-ADRCs from lipoaspirate that have been described in the literature.Uncultured, unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) are a safe and effective treatment option for various musculoskeletal pathologies. However, it is unknown whether the composition of the final cell suspension systematically varies with the subject's individual age, sex, body mass index and ethnicity. UA-ADRCs were isolated from lipoaspirate from n = 232 subjects undergoing elective lipoplasty using the Transpose RT system (InGeneron, Inc.; Houston, TX, USA). The UA-ADRCs were assessed for the number of nucleated cells, cell viability and the number of viable nucleated cells per gram of adipose tissue harvested. Cells from n = 37 subjects were further characterized using four-channel flow cytometry. The present study shows, for the first time, that key characteristics of UA-ADRCs can be independent of the subject's age, sex, BMI and ethnicity. This result has important implications for the general applicability of UA-ADRCs in regeneration of musculoskeletal tissue. Future studies must determine whether the independence of key characteristics of UA-ADRCs of the subject's individual age, sex, BMI and ethnicity only applies to the system used in the present study, or also to others of the more than 25 different experimental methods and commercially available systems used to isolate UA-ADRCs from lipoaspirate that have been described in the literature. |
| Audience | Academic |
| Author | Facile, Tiffany R. Alt, Christopher Maffulli, Nicola Pearce, David A. Schmitz, Christoph Alt, Eckhard U. Furia, John P. Huang, Claire Azares, Alon R. |
| AuthorAffiliation | 3 InGeneron, Inc., Houston, TX 77054, USA 6 Sanford Health, Sioux Falls, SD 57117, USA 11 School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University School of Medicine, Stoke on Trent ST4 7QB, UK 1 Institute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany 7 Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA 2 Isar Klinikum Munich, 80331 Munich, Germany 4 Molecular Cardiology Research Lab, Texas Heart Institute, Houston, TX 77030, USA 5 Sanford Research, Sioux Falls, SD 57104, USA 8 SUN Orthopedics of Evangelical Community Hospital, Lewisburg, PA 17837, USA 9 Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, 84084 Fisciano, Italy 10 Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, London E1 2AD, UK 12 Heart and Vascular Institute, Department of Medicine, Tulane University Health |
| AuthorAffiliation_xml | – name: 9 Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, 84084 Fisciano, Italy – name: 7 Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA – name: 1 Institute of Anatomy, Faculty of Medicine, LMU Munich, 80331 Munich, Germany – name: 8 SUN Orthopedics of Evangelical Community Hospital, Lewisburg, PA 17837, USA – name: 4 Molecular Cardiology Research Lab, Texas Heart Institute, Houston, TX 77030, USA – name: 5 Sanford Research, Sioux Falls, SD 57104, USA – name: 10 Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, Queen Mary University of London, London E1 2AD, UK – name: 2 Isar Klinikum Munich, 80331 Munich, Germany – name: 11 School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University School of Medicine, Stoke on Trent ST4 7QB, UK – name: 3 InGeneron, Inc., Houston, TX 77054, USA – name: 12 Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, New Orleans, LA 70112, USA – name: 6 Sanford Health, Sioux Falls, SD 57117, USA |
| Author_xml | – sequence: 1 givenname: Christoph surname: Schmitz fullname: Schmitz, Christoph – sequence: 2 givenname: Christopher surname: Alt fullname: Alt, Christopher – sequence: 3 givenname: Alon R. surname: Azares fullname: Azares, Alon R. – sequence: 4 givenname: David A. surname: Pearce fullname: Pearce, David A. – sequence: 5 givenname: Tiffany R. surname: Facile fullname: Facile, Tiffany R. – sequence: 6 givenname: John P. surname: Furia fullname: Furia, John P. – sequence: 7 givenname: Nicola orcidid: 0000-0002-5327-3702 surname: Maffulli fullname: Maffulli, Nicola – sequence: 8 givenname: Claire orcidid: 0000-0001-6841-1621 surname: Huang fullname: Huang, Claire – sequence: 9 givenname: Eckhard U. surname: Alt fullname: Alt, Eckhard U. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36611823$$D View this record in MEDLINE/PubMed |
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| Keywords | stem cells microfragmented fat regenerative medicine NucleoCounter UA-ADRCs adipose-derived regenerative cells flow cytometry |
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