Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome

Many naturally occurring agents are believed to protect against UV‐induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB‐induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immor...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Photochemistry and photobiology Ročník 84; číslo 2; s. 307 - 316
Hlavní autoři: El-Mahdy, Mohamed A., Zhu, Qianzheng, Wang, Qi-En, Wani, Gulzar, Patnaik, Srinivas, Zhao, Qun, Arafa, El-Shaimaa, Barakat, Bassant, Mir, Safita N., Wani, Altaf A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.03.2008
Témata:
Amino Acid Sequence
Apoptosis
Apoptosis - drug effects
Apoptosis - radiation effects
Biotechnology
Cell Line
Chemicals
Citrus
Deoxyribonucleic acid
DNA
DNA repair
Flavanones - pharmacology
Free radicals
Genetic disorders
Genome, Human
Human subjects
Humans
Keratinocytes - drug effects
Keratinocytes - radiation effects
Molecular Sequence Data
Monoclonal antibodies
Mortality
Pyrimidine Dimers - isolation & purification
Signal transduction
Ultraviolet Rays
ISSN:0031-8655, 1751-1097
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Many naturally occurring agents are believed to protect against UV‐induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB‐induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53‐mutant human keratinocyte HaCaT cells. The colony‐forming assay shows that treatment with NG significantly increases long‐term cell survival after UVB irradiation. NG treatment also protects the cells from UVB‐induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub‐G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB‐induced poly (ADP‐ribose) polymerase‐1 (PARP‐1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB‐damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB‐irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno‐localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
AbstractList Many naturally occurring agents are believed to protect against UV‐induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB‐induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53‐mutant human keratinocyte HaCaT cells. The colony‐forming assay shows that treatment with NG significantly increases long‐term cell survival after UVB irradiation. NG treatment also protects the cells from UVB‐induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub‐G 1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB‐induced poly (ADP‐ribose) polymerase‐1 (PARP‐1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB‐damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB‐irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno‐localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
AbstractMany naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also protects the cells from UVB-induced apoptosis, as indicated by the absence of the 180base pair DNA ladders and the appearance of sub-G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB-induced poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB-damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB-irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno-localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
UV exposure also causes DNA damage including UV-induced CPD and 6-4PP and these adducts can be removed by nucleotide excision repair (NER). Monoclonal antibodies against actin and XPB were from Neomarkers (Fremont, CA) and Santa Cruz Biotechnology (Santa Cruz, CA), respectively.\n The fact that cyclin A-associated kinase activity is required for entry into S phase, completion of S phase and entry into M phase (61-63) suggests that cyclin/cdk complexes may have a role in DNA repair (64).
Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also protects the cells from UVB-induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub-G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB-induced poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB-damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB-irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno-localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also protects the cells from UVB-induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub-G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB-induced poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB-damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB-irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno-localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a naturally occurring citrus flavonone, on the removal of UVB-induced cyclobutane pyrimidine dimers (CPD) from the genome and apoptosis in immortalized p53-mutant human keratinocyte HaCaT cells. The colony-forming assay shows that treatment with NG significantly increases long-term cell survival after UVB irradiation. NG treatment also protects the cells from UVB-induced apoptosis, as indicated by the absence of the 180 base pair DNA ladders and the appearance of sub-G1 peak using agarose gel electrophoresis and flow cytometric analysis, respectively. The UVB-induced poly (ADP-ribose) polymerase-1 (PARP-1) cleavage, caspase activation and Bax/Bcl2 ratio were modulated following NG treatment, indicating an antiapoptotic effect of NG in UVB-damaged cells that occurs at least in part via caspase cascade pathway. Moreover, treatment of UVB-irradiated HaCaT cells with NG enhances the removal of CPD from the genome, as observed by both direct quantitation of CPD in genomic DNA and immuno-localization of the damage within the nuclei. The study provides a molecular basis for the action of NG as a promising natural flavonoid in preventing skin aging and carcinogenesis.
Author Zhao, Qun
Wani, Altaf A.
Patnaik, Srinivas
Wang, Qi-En
El-Mahdy, Mohamed A.
Arafa, El-Shaimaa
Wani, Gulzar
Zhu, Qianzheng
Mir, Safita N.
Barakat, Bassant
AuthorAffiliation 3 James Cancer Hospital and Research Institute, The Ohio State University, Columbus, OH
1 Department of Radiology, The Ohio State University, Columbus, OH
2 Biochemistry Program, The Ohio State University, Columbus, OH
AuthorAffiliation_xml – name: 1 Department of Radiology, The Ohio State University, Columbus, OH
– name: 2 Biochemistry Program, The Ohio State University, Columbus, OH
– name: 3 James Cancer Hospital and Research Institute, The Ohio State University, Columbus, OH
Author_xml – sequence: 1
  givenname: Mohamed A.
  surname: El-Mahdy
  fullname: El-Mahdy, Mohamed A.
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 2
  givenname: Qianzheng
  surname: Zhu
  fullname: Zhu, Qianzheng
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 3
  givenname: Qi-En
  surname: Wang
  fullname: Wang, Qi-En
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 4
  givenname: Gulzar
  surname: Wani
  fullname: Wani, Gulzar
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 5
  givenname: Srinivas
  surname: Patnaik
  fullname: Patnaik, Srinivas
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 6
  givenname: Qun
  surname: Zhao
  fullname: Zhao, Qun
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 7
  givenname: El-Shaimaa
  surname: Arafa
  fullname: Arafa, El-Shaimaa
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 8
  givenname: Bassant
  surname: Barakat
  fullname: Barakat, Bassant
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 9
  givenname: Safita N.
  surname: Mir
  fullname: Mir, Safita N.
  organization: Department of Radiology, The Ohio State University, Columbus, OH
– sequence: 10
  givenname: Altaf A.
  surname: Wani
  fullname: Wani, Altaf A.
  email: Wani.2@osu.edu
  organization: Department of Radiology, The Ohio State University, Columbus, OH
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18086244$$D View this record in MEDLINE/PubMed
BookMark eNqNktFu0zAUhiM0xLrBKyCLC-5S7CSOEwkhjbC1iGlUqBuXluOctC6JXWxntA_C--KuowNumBXZR_L3_zk5-U-iI200RBEieEzCerMaE0ZJTHDJxgnGbIxxQul48yQaHS6OohHGKYmLnNLj6MS5FcYkKxl5Fh2TAhd5kmWj6OeVsEovQCuNZtZ4kN6hqajEHE2HXmj0CazwShu59eDQ2UIo7Ty6vnkfK90MEhp0tjZrb5xySOgGneul0DKgfgnoC_TmVnTItKjays7Ugxca0GxrVa8aFcoPqgfrUGtNf6eYgDY9PI-etqJz8OL-PI2uL87n1TS-_Dz5WJ1dxpJmBQ07bjEVSZ4IQrMEFyAha3KSlnndQEFIXZZt07a0IJRljSzrhLZJXaRpwyBv6vQ0erf3XQ91D40E7a3o-Dq0J-yWG6H43zdaLfnC3PKE0bwsWTB4fW9gzfcBnOe9chK6LnymGRxnOCNpgf8PJjjLU0poAF_9A67MYHWYAk9SFp40wQF6-Wffh4Z__9cAFHtAWuOchfYBwXwXIb7iu6TwXVL4LkL8LkJ88zCTg1QqHyJgdhNQ3WMM3u4NfqgOto9-MZ9NZ6EI8ngvV87D5iAX9hvPWcoo_3o14dXN_ILOKspx-gsXM_Cx
CODEN PHCBAP
CitedBy_id crossref_primary_10_1016_j_heliyon_2023_e13580
crossref_primary_10_1002_mbo3_697
crossref_primary_10_1080_01635581_2019_1656756
crossref_primary_10_3390_cosmetics10030088
crossref_primary_10_1111_php_14086
crossref_primary_10_3390_f16010079
crossref_primary_10_3109_13880209_2012_695800
crossref_primary_10_1016_j_mrgentox_2014_04_014
crossref_primary_10_1007_s10953_016_0526_2
crossref_primary_10_1016_j_biomaterials_2016_01_018
crossref_primary_10_1208_s12249_020_01766_1
crossref_primary_10_1016_j_jphotobiol_2018_12_001
crossref_primary_10_1155_2013_434057
crossref_primary_10_1016_j_arr_2014_03_002
crossref_primary_10_1016_j_nano_2015_02_024
crossref_primary_10_3390_cosmetics5040058
crossref_primary_10_1039_b801558a
crossref_primary_10_3748_wjg_v22_i44_9775
crossref_primary_10_1080_08982104_2021_1956529
crossref_primary_10_1111_php_13085
crossref_primary_10_3109_01480540903170738
crossref_primary_10_3390_cimb46020094
crossref_primary_10_1177_0748233711413801
crossref_primary_10_1007_s10616_018_0215_7
crossref_primary_10_1155_2022_8638085
crossref_primary_10_1016_j_jnutbio_2016_11_007
crossref_primary_10_3892_etm_2017_4626
crossref_primary_10_1016_j_aca_2014_11_003
crossref_primary_10_1016_j_jdermsci_2009_08_004
crossref_primary_10_3390_antiox9050418
crossref_primary_10_1016_j_jnutbio_2010_08_004
crossref_primary_10_1016_j_ecoenv_2019_02_065
crossref_primary_10_1002_mnfr_200800245
crossref_primary_10_1111_jcmm_12780
crossref_primary_10_1080_01635581_2015_976320
crossref_primary_10_1038_jid_2008_208
crossref_primary_10_1016_j_fitote_2009_06_002
crossref_primary_10_1080_15384101_2016_1158376
crossref_primary_10_1111_dom_12236
crossref_primary_10_1155_2021_5067957
crossref_primary_10_1177_09731296251317254
crossref_primary_10_1016_j_biopha_2018_05_126
crossref_primary_10_1080_14786419_2024_2358392
crossref_primary_10_1016_j_carbpol_2013_07_010
crossref_primary_10_3390_ijms21020554
crossref_primary_10_3390_antiox9030255
crossref_primary_10_1016_j_jphotobiol_2014_04_007
crossref_primary_10_3390_medicines4040075
crossref_primary_10_1007_s00403_009_0999_6
crossref_primary_10_1007_s11095_008_9791_0
crossref_primary_10_3390_ijms21186527
crossref_primary_10_1016_j_foodchem_2012_06_112
crossref_primary_10_1016_j_colsurfa_2015_11_022
crossref_primary_10_2147_DDDT_S326332
crossref_primary_10_1007_s10337_016_3169_y
crossref_primary_10_1016_j_jphotobiol_2015_08_014
crossref_primary_10_1371_journal_pone_0146296
Cites_doi 10.1093/carcin/bgg095
10.1101/gad.13.7.768
10.1074/jbc.M505537200
10.1002/(SICI)1097-4652(199811)177:2<324::AID-JCP14>3.0.CO;2-9
10.1093/carcin/bgg188
10.1189/jlb.69.5.719
10.1038/354314a0
10.1006/excr.2000.4833
10.1016/S0891-5849(01)00829-2
10.1146/annurev.nutr.21.1.381
10.1074/jbc.M200401200
10.1016/S0021-9258(19)74386-5
10.1002/mc.10055
10.1016/j.taap.2003.08.019
10.1093/jnci/88.6.349
10.1016/S1470-2045(00)00029-2
10.1016/j.mrfmmm.2006.06.003
10.1126/science.286.5446.1897
10.1055/s-2007-969247
10.1016/S0968-0004(00)89088-X
10.1111/j.1751-1097.1984.tb04619.x
10.2741/cleaver
10.1016/S0006-2952(02)01386-2
10.1016/S1383-5742(99)00025-3
10.1158/1535-7163.MCT-05-0250
10.1146/annurev.biochem.73.011303.073723
10.1111/j.1751-1097.1999.tb08239.x
10.1016/S1011-1344(98)00182-1
10.2741/afaq
10.1042/bj3560077
10.1038/sj.cdd.4400455
10.1016/0300-9084(96)88150-8
10.1038/sj.onc.1201610
10.1562/2005-07-26-RA-623
10.1038/nrc883
10.1248/bpb.30.32
10.1038/sj.onc.1204883
10.1002/ijc.20587
10.1016/j.freeradbiomed.2004.01.001
10.1016/j.bbcan.2005.04.001
10.1016/S1568-7864(03)00002-8
10.1039/B505311K
10.1111/j.1399-3054.1983.tb04206.x
10.1093/carcin/bgh152
10.1111/j.1751-1097.1996.tb03075.x
10.1111/j.0022-202X.2004.23560.x
10.1093/jnci/89.8.556
10.1083/jcb.106.3.761
10.1016/0092-8674(89)90629-6
10.1016/0031-9422(88)80264-4
10.1038/359599a0
10.1159/000064535
10.1016/0092-8674(91)90293-8
10.1016/S0076-6879(01)35253-9
10.1111/j.1751-1097.1987.tb04798.x
10.1016/S1040-8428(01)00185-8
10.1074/jbc.274.25.17484
10.1073/pnas.95.8.4386
10.1038/374131a0
10.1038/sj.jid.5700510
10.1023/A:1021275330385
10.1083/jcb.200208089
ContentType Journal Article
Copyright 2007 The Authors
Copyright American Society for Photobiology Mar/Apr 2008
2007 The Authors. Journal Compilation. The American Society of Photobiology 0031-8655/08 2007
Copyright_xml – notice: 2007 The Authors
– notice: Copyright American Society for Photobiology Mar/Apr 2008
– notice: 2007 The Authors. Journal Compilation. The American Society of Photobiology 0031-8655/08 2007
DBID BSCLL
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
4T-
7RV
7TM
7U7
7X2
7X7
7XB
88A
88E
88I
8AF
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ATCPS
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
KB0
LK8
M0K
M0S
M1P
M2P
M7P
NAPCQ
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
S0X
7X8
5PM
DOI 10.1111/j.1751-1097.2007.00255.x
DatabaseName Istex
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Docstoc
Nursing & allied health premium.
Nucleic Acids Abstracts
Toxicology Abstracts
Agricultural Science Collection
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Biological Science Collection
Agricultural Science Database
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Science Database
Biological Science Database
Nursing & Allied Health Premium
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
SIRS Editorial
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Agricultural Science Collection
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Docstoc
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
SIRS Editorial
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Agricultural & Environmental Science Collection
ProQuest Central Basic
Toxicology Abstracts
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
Genetics Abstracts
Agricultural Science Database

MEDLINE

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
EISSN 1751-1097
EndPage 316
ExternalDocumentID PMC2756997
1448545691
18086244
10_1111_j_1751_1097_2007_00255_x
PHP255
ark_67375_WNG_CVTF5PC5_0
Genre article
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: CA93413
– fundername: NIEHS NIH HHS
  grantid: R01 ES012991
– fundername: NIEHS NIH HHS
  grantid: ES6074
– fundername: NIEHS NIH HHS
  grantid: ES12991
– fundername: NCI NIH HHS
  grantid: R01 CA093413
– fundername: NIEHS NIH HHS
  grantid: R01 ES002388
GroupedDBID ---
-JH
-~X
.3N
.GA
.GJ
.Y3
05W
0R~
10A
123
1OB
1OC
29O
31~
33P
3O-
3SF
4.4
41~
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5HH
5LA
5RE
5VS
66C
702
7PT
7RV
7X2
7X7
8-0
8-1
8-3
8-4
8-5
88E
88I
8AF
8AO
8FE
8FH
8FI
8FJ
8FW
8R4
8R5
8UM
8WZ
930
A03
A6W
AAESR
AAEVG
AAHQN
AAMMB
AAMNL
AANHP
AANLZ
AAONW
AAPSS
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABDPE
ABEFU
ABEML
ABUWG
ACAHQ
ACBWZ
ACCZN
ACGFO
ACGFS
ACGOD
ACNCT
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADEOM
ADHSS
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADZMN
AEFGJ
AEIGN
AEIMD
AENEX
AEPYG
AEUYN
AEUYR
AEYWJ
AFBPY
AFFHD
AFFIJ
AFFPM
AFGKR
AFKRA
AFNWH
AFRAH
AFWVQ
AFZJQ
AGHNM
AGQPQ
AGXDD
AGYGG
AHBTC
AHEFC
AHMBA
AIAGR
AIDQK
AIDYY
AIQQE
AITYG
AIURR
AJXKR
AKPMI
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATCPS
ATUGU
AUFTA
AVWKF
AZBYB
AZFZN
AZQEC
AZVAB
BAFTC
BBNVY
BDRZF
BENPR
BFHJK
BHBCM
BHPHI
BKEYQ
BLYAC
BMNLL
BNHUX
BPHCQ
BROTX
BRXPI
BSCLL
BVXVI
BY8
C1A
CAG
CCPQU
COF
CS3
D-E
D-F
DC7
DCZOG
DPXWK
DR2
DRFUL
DRSTM
DU5
DWQXO
E3Z
EBS
ECGQY
EJD
EX3
F00
F01
F04
F5P
FEDTE
FYUFA
FZ0
G-S
G.N
GNUQQ
GODZA
H.T
H.X
H13
HCIFZ
HF~
HGLYW
HMCUK
HVGLF
HZ~
H~9
IH2
IX1
J0M
K48
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LK8
LOXES
LP6
LP7
LUTES
LW6
LYRES
M0K
M1P
M2P
M2Q
M7P
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MXFUL
MXSTM
N04
N05
N9A
NAPCQ
NDZJH
NF~
O66
O9-
OIG
P2P
P2W
P2X
P4D
PALCI
PHGZM
PHGZT
PJZUB
PPXIY
PQ0
PQGLB
PQQKQ
PROAC
PSQYO
Q.N
Q11
Q2X
Q5J
QB0
R.K
RBO
RIWAO
RJQFR
ROL
RWL
RX1
S0X
SAMSI
SJN
SUPJJ
TAE
UB1
UKHRP
W8V
W99
WBKPD
WH7
WIH
WIK
WNSPC
WOHZO
WOW
WQJ
WXSBR
WYISQ
XG1
XOL
YNT
ZGI
ZXP
ZZTAW
~02
~IA
~KM
~WT
PUEGO
AAYXX
CITATION
O8X
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
RIG
3V.
4T-
7TM
7U7
7XB
88A
8FD
8FK
C1K
FR3
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c5485-c50f05a262a154208ece4d61396bde811b99fdff581574dc9b25f2b833d7e6db3
IEDL.DBID DRFUL
ISSN 0031-8655
IngestDate Tue Nov 04 01:39:05 EST 2025
Wed Oct 01 14:16:56 EDT 2025
Tue Oct 07 09:35:29 EDT 2025
Mon Oct 06 17:16:40 EDT 2025
Mon Jul 21 05:44:56 EDT 2025
Sat Nov 29 03:31:39 EST 2025
Tue Nov 18 21:44:31 EST 2025
Sun Sep 21 06:19:02 EDT 2025
Tue Nov 11 03:33:23 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5485-c50f05a262a154208ece4d61396bde811b99fdff581574dc9b25f2b833d7e6db3
Notes ArticleID:PHP255
istex:76457760FC5A5085BD18A596869BA3BDF2BD18A6
ark:/67375/WNG-CVTF5PC5-0
This paper is part of a special issue dedicated to Professor Hasan Mukhtar on the occasion of his 60th birthday.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
OpenAccessLink http://doi.org/10.1111/j.1751-1097.2007.00255.x
PMID 18086244
PQID 237237320
PQPubID 30729
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_2756997
proquest_miscellaneous_70413807
proquest_miscellaneous_20463515
proquest_journals_237237320
pubmed_primary_18086244
crossref_primary_10_1111_j_1751_1097_2007_00255_x
crossref_citationtrail_10_1111_j_1751_1097_2007_00255_x
wiley_primary_10_1111_j_1751_1097_2007_00255_x_PHP255
istex_primary_ark_67375_WNG_CVTF5PC5_0
PublicationCentury 2000
PublicationDate March/April 2008
PublicationDateYYYYMMDD 2008-03-01
PublicationDate_xml – month: 03
  year: 2008
  text: March/April 2008
PublicationDecade 2000
PublicationPlace Oxford, UK
PublicationPlace_xml – name: Oxford, UK
– name: United States
– name: Lawrence
PublicationTitle Photochemistry and photobiology
PublicationTitleAlternate Photochem Photobiol
PublicationYear 2008
Publisher Blackwell Publishing Ltd
Publisher_xml – name: Blackwell Publishing Ltd
References Girard, F., U. Strausfeld, A. Fernandez and N. J. Lamb (1991) Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179.
Williams, R. J., J. P. Spencer and C. Rice-Evans (2004) Flavonoids: Antioxidants or signalling molecules? Free Radic. Biol. Med. 36, 838-849.
Matsumura, Y. and H. N. Ananthaswamy (2004) Toxic effects of ultraviolet radiation on the skin. Toxicol. Appl. Pharmacol. 195, 298-308.
Cleaver, J. E. and E. Crowley (2002) UV damage, DNA repair and skin carcinogenesis. Front Biosci. 7, d1024-d1043.
Placzek, M., S. Gaube, U. Kerkmann, K. P. Gilbertz, T. Herzinger, E. Haen and B. Przybilla (2005) Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol. J. Invest. Dermatol. 124, 304-307.
Nguyen, M., D. G. Millar, V. W. Yong, S. J. Korsmeyer and G. C. Shore (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J. Biol. Chem. 268, 25265-25268.
Sitailo, L. A., S. S. Tibudan and M. F. Denning (2002) Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J. Biol. Chem. 277, 19346-19352.
Gillardon, F., I. Moll, M. Meyer and T. M. Michaelidis (1999) Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ. 6, 55-60.
Lee, E. R., Y. J. Kang, J. H. Kim, H. T. Lee and S. G. Cho (2005) Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J. Biol. Chem. 280, 31498-31507.
Sarasin, A. (1999) The molecular pathways of ultraviolet-induced carcinogenesis. Mutat. Res. 428, 5-10.
Latonen, L., Y. Taya and M. Laiho (2001) UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 20, 6784-6793.
Lehner, C. F. and P. H. O'Farrell (1989) Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56, 957-968.
Cory, S. and J. M. Adams (2002) The Bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656.
Pena, J. C., E. Fuchs and C. B. Thompson (1997) Bcl-x expression influences keratinocyte cell survival but not terminal differentiation. Cell Growth Differ. 8, 619-629.
Afaq, F., D. N. Syed, A. Malik, N. Hadi, S. Sarfaraz, M. H. Kweon, N. Khan, M. A. Zaid and H. Mukhtar (2007) Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis. J. Invest. Dermatol. 127, 222-232.
Walker, D. H. and J. L. Maller (1991) Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature 354, 314-317.
Dhanalakshmi, S., G. U. Mallikarjuna, R. P. Singh and R. Agarwal (2004) Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 25, 99-106.
Rodriguez-Villanueva, J., D. Greenhalgh, X. J. Wang, D. Bundman, S. Cho, M. Delehedde, D. Roop and T. J. McDonnell (1998) Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene 16, 853-863.
Afaq, F., V. M. Adhami, N. Ahmad and H. Mukhtar (2002) Botanical antioxidants for chemoprevention of photocarcinogenesis. Front Biosci. 7, d784-d792.
Loeffler, M. and G. Kroemer (2000) The mitochondrion in cell death control: Certainties and incognita. Exp. Cell Res. 256, 19-26.
Gupta, S. and H. Mukhtar (2002) Chemoprevention of skin cancer: Current status and future prospects. Cancer Metastasis Rev. 21, 363-380.
Einspahr, J. G., S. P. Stratton, G. T. Bowden and D. S. Alberts (2002) Chemoprevention of human skin cancer. Crit. Rev. Oncol. Hematol. 41, 269-285.
Morel, I., V. Abalea, P. Cillard and J. Cillard (2001) Repair of oxidized DNA by the flavonoid myricetin. Methods Enzymol. 335, 308-316.
Bernardi, R., C. Negri, M. Donzelli, F. Guano, M. Torti, E. Prosperi and A. I. Scovassi (1995) Activation of poly(ADP-ribose)polymerase in apoptotic human cells. Biochimie 77, 378-384.
Reagan-Shaw, S., J. Breur and N. Ahmad (2006) Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes. Mol. Cancer Ther. 5, 418-429.
Feng, Z., W. Hu, L. J. Marnett and M. S. Tang (2006) Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat. Res. 601, 125-136.
De Laat, A., M. Van Tilburg, J. C. Van Der Leun, W. A. Van Vloten and F. R. De Gruijl (1996) Cell cycle kinetics following UVA irradiation in comparison to UVB and UVC irradiation. Photochem. Photobiol. 63, 492-497.
Wani, A. A., S. M. D'Ambrosio and N. K. Alvi (1987) Quantitation of pyrimidine dimers by immunoslot blot following sublethal UV-irradiation of human cells. Photochem. Photobiol. 46, 477-482.
Stewart, B. W., P. Kleihues, B. W. Stewart and Y. Kletter (2003) World Cancer Report. IARC Press, Washington, DC.
Caldwell, M. M., R. Robberecht and S. D. Flint (1983) Internal filters: Prospects for UV-acclimation in higher plants. Physiol. Plant 58, 445-450.
Assefa, Z., L. A. Van, M. Garmyn and P. Agostinis (2005) Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors. Biochim. Biophys. Acta 1755, 90-106.
Chen, Y. C., S. Y. Lin-Shiau and J. K. Lin (1998) Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell. Physiol. 177, 324-333.
Bossy-Wetzel, E. and D. R. Green (1999) Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem. 274, 17484-17490.
Park, C. H., M. J. Lee, J. P. Kim, I. D. Yoo and J. H. Chung (2006) Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A. Photochem. Photobiol. 82, 574-578.
Lehmann, A. R. (1995) Nucleotide excision repair and the link with transcription. Trends Biochem. Sci. 20, 402-405.
Herzinger, T., J. O. Funk, K. Hillmer, D. Eick, D. A. Wolf and P. Kind (1995) Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 11, 2151-2156.
Baliga, M. S. and S. K. Katiyar (2006) Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem. Photobiol. Sci. 5, 243-253.
Wang, Q., Q. Zhu, M. A. Wani, G. Wani, J. Chen and A. A. Wani (2003) Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. DNA Repair 2, 483-499.
Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham and N. E. Fusenig (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771.
Dhanalakshmi, S., G. U. Mallikarjuna, R. P. Singh and R. Agarwal (2004) Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis 25, 1459-1465.
Gailani, M. R., D. J. Leffell, A. Ziegler, E. G. Gross, D. E. Brash and A. E. Bale (1996) Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J. Natl Cancer Inst. 88, 349-354.
Afaq, F., M. Saleem, C. G. Krueger, J. D. Reed and H. Mukhtar (2005) Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer 113, 423-433.
Madronich, S., R. L. McKenzie, L. O. Bjorn and M. M. Caldwell (1998) Changes in biologically active ultraviolet radiation reaching the Earth's surface. J. Photochem. Photobiol. B 46, 5-19.
De Gruijl, F. R. (2002) Photocarcinogenesis: UVA vs. UVB radiation. Skin Pharmacol. Appl. Skin Physiol. 15, 316-320.
Mittal, A., C. A. Elmets and S. K. Katiyar (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation. Carcinogenesis 24, 1379-1388.
Sancar, A., L. A. Lindsey-Boltz, K. Unsal-Kacmaz and S. Linn (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85.
Petrocelli, T., R. Poon, D. J. Drucker, J. M. Slingerland and C. F. Rosen (1996) UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints. Oncogene 12, 1387-1396.
Ricci, J. E., R. A. Gottlieb and D. R. Green (2003) Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J. Cell Biol. 160, 65-75.
Chen, Y. C., S. C. Shen, W. R. Lee, F. L. Hsu, H. Y. Lin, C. H. Ko and S. W. Tseng (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem. Pharmacol. 64, 1713-1724.
Yang, C. S., J. M. Landau, M. T. Huang and H. L. Newmark (2001) Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21, 381-406.
Katiyar, S. K. and H. Mukhtar (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. J. Leukoc. Biol. 69, 719-726.
Wani, A. A., R. E. Gibson-D'Ambrosio and S. M. D'Ambrosio (1984) Antibodies to UV irradiated DNA: The monitoring of DNA damage by ELISA and indirect immunofluorescence. Photochem. Photobiol. 40, 465-471.
Murray, A. W. (1992) Creative blocks: Cell-cycle checkpoints and feedback controls. Nature 359, 599-604.
Hu, Y., M. A. Benedict, D. Wu, N. Inohara and G. Nunez (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl Acad. Sci. USA 95, 4386-4391.
Herzi
2002; 15
1991; 354
2000; 256
2004; 25
1995; 77
1997; 89
2002; 277
1999; 286
2000; 1
2007; 30
1995; 374
2005; 1755
1983; 58
1988; 106
1998; 46
1997; 8
1995; 20
1987; 46
1998; 16
2004; 73
2002; 41
2004; 36
1999; 13
2003; 2
1992; 359
2003; 160
1996; 63
1998; 95
2006; 601
2001; 335
1984; 40
2007; 127
1986; 52
2005; 113
2002; 34
2002; 7
1995; 11
2002; 32
1995; 10
2002; 2
2006; 5
2003
1998; 177
1993; 268
1999; 6
2001; 69
1996; 12
2001; 20
1999; 428
2001; 21
2006; 82
2005; 280
1989; 56
1991; 67
2002; 64
2005; 124
2004; 195
1988; 27
2002; 21
1999; 274
2003; 24
2001; 33
1999; 70
2001; 356
1996; 88
e_1_2_6_51_2
e_1_2_6_53_2
e_1_2_6_30_2
Catani M. V. (e_1_2_6_44_2) 2001; 356
e_1_2_6_13_2
e_1_2_6_34_2
e_1_2_6_59_2
e_1_2_6_11_2
e_1_2_6_32_2
e_1_2_6_17_2
e_1_2_6_38_2
e_1_2_6_55_2
e_1_2_6_15_2
e_1_2_6_36_2
e_1_2_6_62_2
e_1_2_6_64_2
e_1_2_6_20_2
e_1_2_6_60_2
Stewart B. W. (e_1_2_6_4_2) 2003
Petrocelli T. (e_1_2_6_57_2) 1996; 12
e_1_2_6_7_2
e_1_2_6_9_2
e_1_2_6_3_2
e_1_2_6_5_2
e_1_2_6_24_2
e_1_2_6_47_2
e_1_2_6_22_2
e_1_2_6_49_2
e_1_2_6_28_2
e_1_2_6_43_2
e_1_2_6_66_2
e_1_2_6_26_2
e_1_2_6_45_2
e_1_2_6_68_2
e_1_2_6_50_2
e_1_2_6_31_2
e_1_2_6_18_2
e_1_2_6_12_2
e_1_2_6_35_2
e_1_2_6_58_2
e_1_2_6_10_2
e_1_2_6_33_2
e_1_2_6_16_2
e_1_2_6_39_2
e_1_2_6_54_2
e_1_2_6_14_2
e_1_2_6_37_2
e_1_2_6_56_2
e_1_2_6_63_2
e_1_2_6_42_2
Pena J. C. (e_1_2_6_52_2) 1997; 8
e_1_2_6_40_2
Narayana K. R. (e_1_2_6_19_2) 2001; 33
e_1_2_6_8_2
e_1_2_6_29_2
e_1_2_6_6_2
Herzinger T. (e_1_2_6_61_2) 1995; 10
e_1_2_6_23_2
e_1_2_6_48_2
e_1_2_6_69_2
e_1_2_6_2_2
e_1_2_6_21_2
e_1_2_6_65_2
e_1_2_6_27_2
Herzinger T. (e_1_2_6_41_2) 1995; 11
e_1_2_6_67_2
e_1_2_6_25_2
e_1_2_6_46_2
References_xml – reference: Murray, A. W. (1992) Creative blocks: Cell-cycle checkpoints and feedback controls. Nature 359, 599-604.
– reference: Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham and N. E. Fusenig (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771.
– reference: Sancar, A., L. A. Lindsey-Boltz, K. Unsal-Kacmaz and S. Linn (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39-85.
– reference: Assefa, Z., L. A. Van, M. Garmyn and P. Agostinis (2005) Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors. Biochim. Biophys. Acta 1755, 90-106.
– reference: Caldwell, M. M., R. Robberecht and S. D. Flint (1983) Internal filters: Prospects for UV-acclimation in higher plants. Physiol. Plant 58, 445-450.
– reference: Sarasin, A. (1999) The molecular pathways of ultraviolet-induced carcinogenesis. Mutat. Res. 428, 5-10.
– reference: Chen, Y. C., S. C. Shen, W. R. Lee, F. L. Hsu, H. Y. Lin, C. H. Ko and S. W. Tseng (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem. Pharmacol. 64, 1713-1724.
– reference: Wang, Q., Q. Zhu, M. A. Wani, G. Wani, J. Chen and A. A. Wani (2003) Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage. DNA Repair 2, 483-499.
– reference: Afaq, F., V. M. Adhami, N. Ahmad and H. Mukhtar (2002) Botanical antioxidants for chemoprevention of photocarcinogenesis. Front Biosci. 7, d784-d792.
– reference: Maalouf, S., M. El-Sabban, N. Darwiche and H. Gali-Muhtasib (2002) Protective effect of vitamin E on ultraviolet B light-induced damage in keratinocytes. Mol. Carcinog. 34, 121-130.
– reference: Wani, A. A., R. E. Gibson-D'Ambrosio and S. M. D'Ambrosio (1984) Antibodies to UV irradiated DNA: The monitoring of DNA damage by ELISA and indirect immunofluorescence. Photochem. Photobiol. 40, 465-471.
– reference: Chen, Y. C., S. Y. Lin-Shiau and J. K. Lin (1998) Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell. Physiol. 177, 324-333.
– reference: Lehner, C. F. and P. H. O'Farrell (1989) Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56, 957-968.
– reference: Matsumura, Y. and H. N. Ananthaswamy (2004) Toxic effects of ultraviolet radiation on the skin. Toxicol. Appl. Pharmacol. 195, 298-308.
– reference: Wani, A. A., S. M. D'Ambrosio and N. K. Alvi (1987) Quantitation of pyrimidine dimers by immunoslot blot following sublethal UV-irradiation of human cells. Photochem. Photobiol. 46, 477-482.
– reference: Hu, Y., M. A. Benedict, D. Wu, N. Inohara and G. Nunez (1998) Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl Acad. Sci. USA 95, 4386-4391.
– reference: Katiyar, S. K., N. J. Korman, H. Mukhtar and R. Agarwal (1997) Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J. Natl Cancer Inst. 89, 556-566.
– reference: Cleaver, J. E. and E. Crowley (2002) UV damage, DNA repair and skin carcinogenesis. Front Biosci. 7, d1024-d1043.
– reference: Lehmann, A. R. (1995) Nucleotide excision repair and the link with transcription. Trends Biochem. Sci. 20, 402-405.
– reference: Loeffler, M. and G. Kroemer (2000) The mitochondrion in cell death control: Certainties and incognita. Exp. Cell Res. 256, 19-26.
– reference: Lindahl, T. and R. D. Wood (1999) Quality control by DNA repair. Science 286, 1897-1905.
– reference: Park, C. H., M. J. Lee, J. P. Kim, I. D. Yoo and J. H. Chung (2006) Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A. Photochem. Photobiol. 82, 574-578.
– reference: Reagan-Shaw, S., J. Breur and N. Ahmad (2006) Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes. Mol. Cancer Ther. 5, 418-429.
– reference: Catani, M. V., A. Rossi, A. Costanzo, S. Sabatini, M. Levrero, G. Melino and L. Avigliano (2001) Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage. Biochem. J. 356, 77-85.
– reference: Stewart, B. W., P. Kleihues, B. W. Stewart and Y. Kletter (2003) World Cancer Report. IARC Press, Washington, DC.
– reference: Katiyar, S. K. and H. Mukhtar (2001) Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. J. Leukoc. Biol. 69, 719-726.
– reference: De Laat, A., M. Van Tilburg, J. C. Van Der Leun, W. A. Van Vloten and F. R. De Gruijl (1996) Cell cycle kinetics following UVA irradiation in comparison to UVB and UVC irradiation. Photochem. Photobiol. 63, 492-497.
– reference: Morel, I., V. Abalea, P. Cillard and J. Cillard (2001) Repair of oxidized DNA by the flavonoid myricetin. Methods Enzymol. 335, 308-316.
– reference: Petrocelli, T., R. Poon, D. J. Drucker, J. M. Slingerland and C. F. Rosen (1996) UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints. Oncogene 12, 1387-1396.
– reference: De Laat, W. L., N. G. Jaspers and J. H. Hoeijmakers (1999) Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768-785.
– reference: Baliga, M. S. and S. K. Katiyar (2006) Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem. Photobiol. Sci. 5, 243-253.
– reference: Herzinger, T., D. A. Wolf, D. Eick and P. Kind (1995) The pRb-related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes. Oncogene 10, 2079-2084.
– reference: Lee, E. R., J. H. Kim, Y. J. Kang and S. G. Cho (2007) The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes. Biol. Pharm. Bull. 30, 32-37.
– reference: Placzek, M., S. Gaube, U. Kerkmann, K. P. Gilbertz, T. Herzinger, E. Haen and B. Przybilla (2005) Ultraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol. J. Invest. Dermatol. 124, 304-307.
– reference: Feng, Z., W. Hu, L. J. Marnett and M. S. Tang (2006) Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair. Mutat. Res. 601, 125-136.
– reference: Bernardi, R., C. Negri, M. Donzelli, F. Guano, M. Torti, E. Prosperi and A. I. Scovassi (1995) Activation of poly(ADP-ribose)polymerase in apoptotic human cells. Biochimie 77, 378-384.
– reference: De Gruijl, F. R. (2002) Photocarcinogenesis: UVA vs. UVB radiation. Skin Pharmacol. Appl. Skin Physiol. 15, 316-320.
– reference: Latonen, L., Y. Taya and M. Laiho (2001) UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 20, 6784-6793.
– reference: Narayana, K. R., M. S. Reddy, M. R. Chaluvadi and D. R. Krishna (2001) Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J. Pharmacol. 33, 2-16.
– reference: Bossy-Wetzel, E. and D. R. Green (1999) Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem. 274, 17484-17490.
– reference: Walker, D. H. and J. L. Maller (1991) Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature 354, 314-317.
– reference: Gupta, S. and H. Mukhtar (2002) Chemoprevention of skin cancer: Current status and future prospects. Cancer Metastasis Rev. 21, 363-380.
– reference: Pena, J. C., E. Fuchs and C. B. Thompson (1997) Bcl-x expression influences keratinocyte cell survival but not terminal differentiation. Cell Growth Differ. 8, 619-629.
– reference: Bode, A. M. and Z. Dong (2000) Signal transduction pathways: Targets for chemoprevention of skin cancer. Lancet Oncol. 1, 181-188.
– reference: Ricci, J. E., R. A. Gottlieb and D. R. Green (2003) Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J. Cell Biol. 160, 65-75.
– reference: Pourzand, C. and R. M. Tyrrell (1999) Apoptosis, the role of oxidative stress and the example of solar UV radiation. Photochem. Photobiol. 70, 380-390.
– reference: Gailani, M. R., D. J. Leffell, A. Ziegler, E. G. Gross, D. E. Brash and A. E. Bale (1996) Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J. Natl Cancer Inst. 88, 349-354.
– reference: Williams, R. J., J. P. Spencer and C. Rice-Evans (2004) Flavonoids: Antioxidants or signalling molecules? Free Radic. Biol. Med. 36, 838-849.
– reference: Girard, F., U. Strausfeld, A. Fernandez and N. J. Lamb (1991) Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179.
– reference: Einspahr, J. G., S. P. Stratton, G. T. Bowden and D. S. Alberts (2002) Chemoprevention of human skin cancer. Crit. Rev. Oncol. Hematol. 41, 269-285.
– reference: Mittal, A., C. A. Elmets and S. K. Katiyar (2003) Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: Relationship to decreased fat and lipid peroxidation. Carcinogenesis 24, 1379-1388.
– reference: Yang, C. S., J. M. Landau, M. T. Huang and H. L. Newmark (2001) Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr. 21, 381-406.
– reference: Mori, A., C. Nishinoc, N. Enoki and S. Tawata (1988) Cytotoxicity of plant flavonoids against Hela cells. Phytochemistry 27, 1017-1020.
– reference: Dhanalakshmi, S., G. U. Mallikarjuna, R. P. Singh and R. Agarwal (2004) Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. Carcinogenesis 25, 1459-1465.
– reference: Dhanalakshmi, S., G. U. Mallikarjuna, R. P. Singh and R. Agarwal (2004) Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes. Carcinogenesis 25, 99-106.
– reference: Sitailo, L. A., S. S. Tibudan and M. F. Denning (2002) Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J. Biol. Chem. 277, 19346-19352.
– reference: Afaq, F., D. N. Syed, A. Malik, N. Hadi, S. Sarfaraz, M. H. Kweon, N. Khan, M. A. Zaid and H. Mukhtar (2007) Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis. J. Invest. Dermatol. 127, 222-232.
– reference: Morgan, D. O. (1995) Principles of CDK regulation. Nature 374, 131-134.
– reference: Cory, S. and J. M. Adams (2002) The Bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656.
– reference: Gillardon, F., I. Moll, M. Meyer and T. M. Michaelidis (1999) Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ. 6, 55-60.
– reference: Valenzuela, A., R. Guerra and L. A. Videla (1986) Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med. 52, 438-440.
– reference: Madronich, S., R. L. McKenzie, L. O. Bjorn and M. M. Caldwell (1998) Changes in biologically active ultraviolet radiation reaching the Earth's surface. J. Photochem. Photobiol. B 46, 5-19.
– reference: Phillipson, R. P., S. E. Tobi, J. A. Morris and T. J. McMillan (2002) UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. Free Radic. Biol. Med. 32, 474-480.
– reference: Lee, E. R., Y. J. Kang, J. H. Kim, H. T. Lee and S. G. Cho (2005) Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J. Biol. Chem. 280, 31498-31507.
– reference: Nguyen, M., D. G. Millar, V. W. Yong, S. J. Korsmeyer and G. C. Shore (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J. Biol. Chem. 268, 25265-25268.
– reference: Afaq, F., M. Saleem, C. G. Krueger, J. D. Reed and H. Mukhtar (2005) Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer 113, 423-433.
– reference: Herzinger, T., J. O. Funk, K. Hillmer, D. Eick, D. A. Wolf and P. Kind (1995) Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 11, 2151-2156.
– reference: Rodriguez-Villanueva, J., D. Greenhalgh, X. J. Wang, D. Bundman, S. Cho, M. Delehedde, D. Roop and T. J. McDonnell (1998) Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene 16, 853-863.
– volume: 177
  start-page: 324
  year: 1998
  end-page: 333
  article-title: Involvement of reactive oxygen species and caspase 3 activation in arsenite‐induced apoptosis
  publication-title: J. Cell. Physiol.
– volume: 64
  start-page: 1713
  year: 2002
  end-page: 1724
  article-title: Emodin induces apoptosis in human promyeloleukemic HL‐60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production
  publication-title: Biochem. Pharmacol.
– volume: 70
  start-page: 380
  year: 1999
  end-page: 390
  article-title: Apoptosis, the role of oxidative stress and the example of solar UV radiation
  publication-title: Photochem. Photobiol.
– volume: 268
  start-page: 25265
  year: 1993
  end-page: 25268
  article-title: Targeting of Bcl‐2 to the mitochondrial outer membrane by a COOH‐terminal signal anchor sequence
  publication-title: J. Biol. Chem.
– volume: 34
  start-page: 121
  year: 2002
  end-page: 130
  article-title: Protective effect of vitamin E on ultraviolet B light‐induced damage in keratinocytes
  publication-title: Mol. Carcinog.
– volume: 8
  start-page: 619
  year: 1997
  end-page: 629
  article-title: Bcl‐x expression influences keratinocyte cell survival but not terminal differentiation
  publication-title: Cell Growth Differ.
– volume: 25
  start-page: 1459
  year: 2004
  end-page: 1465
  article-title: Silibinin prevents ultraviolet radiation‐caused skin damages in SKH‐1 hairless mice via a decrease in thymine dimer positive cells and an up‐regulation of p53‐p21/Cip1 in epidermis
  publication-title: Carcinogenesis
– volume: 359
  start-page: 599
  year: 1992
  end-page: 604
  article-title: Creative blocks: Cell‐cycle checkpoints and feedback controls
  publication-title: Nature
– volume: 21
  start-page: 363
  year: 2002
  end-page: 380
  article-title: Chemoprevention of skin cancer: Current status and future prospects
  publication-title: Cancer Metastasis Rev.
– volume: 113
  start-page: 423
  year: 2005
  end-page: 433
  article-title: Anthocyanin‐ and hydrolyzable tannin‐rich pomegranate fruit extract modulates MAPK and NF‐kappaB pathways and inhibits skin tumorigenesis in CD‐1 mice
  publication-title: Int. J. Cancer
– volume: 36
  start-page: 838
  year: 2004
  end-page: 849
  article-title: Flavonoids: Antioxidants or signalling molecules?
  publication-title: Free Radic. Biol. Med.
– volume: 13
  start-page: 768
  year: 1999
  end-page: 785
  article-title: Molecular mechanism of nucleotide excision repair
  publication-title: Genes Dev.
– volume: 77
  start-page: 378
  year: 1995
  end-page: 384
  article-title: Activation of poly(ADP‐ribose)polymerase in apoptotic human cells
  publication-title: Biochimie
– volume: 256
  start-page: 19
  year: 2000
  end-page: 26
  article-title: The mitochondrion in cell death control: Certainties and incognita
  publication-title: Exp. Cell Res.
– volume: 20
  start-page: 402
  year: 1995
  end-page: 405
  article-title: Nucleotide excision repair and the link with transcription
  publication-title: Trends Biochem. Sci.
– volume: 27
  start-page: 1017
  year: 1988
  end-page: 1020
  article-title: Cytotoxicity of plant flavonoids against Hela cells
  publication-title: Phytochemistry
– volume: 335
  start-page: 308
  year: 2001
  end-page: 316
  article-title: Repair of oxidized DNA by the flavonoid myricetin
  publication-title: Methods Enzymol.
– volume: 52
  start-page: 438
  year: 1986
  end-page: 440
  article-title: Antioxidant properties of the flavonoids silybin and (+)‐cyanidanol‐3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene
  publication-title: Planta Med.
– volume: 106
  start-page: 761
  year: 1988
  end-page: 771
  article-title: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
  publication-title: J. Cell Biol.
– volume: 280
  start-page: 31498
  year: 2005
  end-page: 31507
  article-title: Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids
  publication-title: J. Biol. Chem.
– volume: 89
  start-page: 556
  year: 1997
  end-page: 566
  article-title: Protective effects of silymarin against photocarcinogenesis in a mouse skin model
  publication-title: J. Natl Cancer Inst.
– volume: 5
  start-page: 243
  year: 2006
  end-page: 253
  article-title: Chemoprevention of photocarcinogenesis by selected dietary botanicals
  publication-title: Photochem. Photobiol. Sci.
– volume: 73
  start-page: 39
  year: 2004
  end-page: 85
  article-title: Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
  publication-title: Annu. Rev. Biochem.
– volume: 195
  start-page: 298
  year: 2004
  end-page: 308
  article-title: Toxic effects of ultraviolet radiation on the skin
  publication-title: Toxicol. Appl. Pharmacol.
– volume: 67
  start-page: 1169
  year: 1991
  end-page: 1179
  article-title: Cyclin A is required for the onset of DNA replication in mammalian fibroblasts
  publication-title: Cell
– volume: 1755
  start-page: 90
  year: 2005
  end-page: 106
  article-title: Ultraviolet radiation‐induced apoptosis in keratinocytes: On the role of cytosolic factors
  publication-title: Biochim. Biophys. Acta
– volume: 69
  start-page: 719
  year: 2001
  end-page: 726
  article-title: Green tea polyphenol (‐)‐epigallocatechin‐3‐gallate treatment to mouse skin prevents UVB‐induced infiltration of leukocytes, depletion of antigen‐presenting cells, and oxidative stress
  publication-title: J. Leukoc. Biol.
– volume: 41
  start-page: 269
  year: 2002
  end-page: 285
  article-title: Chemoprevention of human skin cancer
  publication-title: Crit. Rev. Oncol. Hematol.
– volume: 277
  start-page: 19346
  year: 2002
  end-page: 19352
  article-title: Activation of caspase‐9 is required for UV‐induced apoptosis of human keratinocytes
  publication-title: J. Biol. Chem.
– volume: 160
  start-page: 65
  year: 2003
  end-page: 75
  article-title: Caspase‐mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis
  publication-title: J. Cell Biol.
– volume: 95
  start-page: 4386
  year: 1998
  end-page: 4391
  article-title: Bcl‐XL interacts with Apaf‐1 and inhibits Apaf‐1‐dependent caspase‐9 activation
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 11
  start-page: 2151
  year: 1995
  end-page: 2156
  article-title: Ultraviolet B irradiation‐induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase
  publication-title: Oncogene
– volume: 88
  start-page: 349
  year: 1996
  end-page: 354
  article-title: Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma
  publication-title: J. Natl Cancer Inst.
– volume: 46
  start-page: 477
  year: 1987
  end-page: 482
  article-title: Quantitation of pyrimidine dimers by immunoslot blot following sublethal UV‐irradiation of human cells
  publication-title: Photochem. Photobiol.
– volume: 2
  start-page: 647
  year: 2002
  end-page: 656
  article-title: The Bcl2 family: Regulators of the cellular life‐or‐death switch
  publication-title: Nat. Rev. Cancer
– volume: 428
  start-page: 5
  year: 1999
  end-page: 10
  article-title: The molecular pathways of ultraviolet‐induced carcinogenesis
  publication-title: Mutat. Res.
– volume: 25
  start-page: 99
  year: 2004
  end-page: 106
  article-title: Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation‐caused apoptosis in HaCaT human immortalized keratinocytes
  publication-title: Carcinogenesis
– volume: 274
  start-page: 17484
  year: 1999
  end-page: 17490
  article-title: Caspases induce cytochrome c release from mitochondria by activating cytosolic factors
  publication-title: J. Biol. Chem.
– volume: 12
  start-page: 1387
  year: 1996
  end-page: 1396
  article-title: UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints
  publication-title: Oncogene
– volume: 20
  start-page: 6784
  year: 2001
  end-page: 6793
  article-title: UV‐radiation induces dose‐dependent regulation of p53 response and modulates p53‐HDM2 interaction in human fibroblasts
  publication-title: Oncogene
– volume: 354
  start-page: 314
  year: 1991
  end-page: 317
  article-title: Role for cyclin A in the dependence of mitosis on completion of DNA replication
  publication-title: Nature
– year: 2003
– volume: 6
  start-page: 55
  year: 1999
  end-page: 60
  article-title: Alterations in cell death and cell cycle progression in the UV‐irradiated epidermis of bcl‐2‐deficient mice
  publication-title: Cell Death Differ.
– volume: 10
  start-page: 2079
  year: 1995
  end-page: 2084
  article-title: The pRb‐related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes
  publication-title: Oncogene
– volume: 7
  start-page: d784
  year: 2002
  end-page: d792
  article-title: Botanical antioxidants for chemoprevention of photocarcinogenesis
  publication-title: Front Biosci.
– volume: 2
  start-page: 483
  year: 2003
  end-page: 499
  article-title: Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage
  publication-title: DNA Repair
– volume: 124
  start-page: 304
  year: 2005
  end-page: 307
  article-title: Ultraviolet B‐induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D‐alpha‐tocopherol
  publication-title: J. Invest. Dermatol.
– volume: 30
  start-page: 32
  year: 2007
  end-page: 37
  article-title: The anti‐apoptotic and anti‐oxidant effect of eriodictyol on UV‐induced apoptosis in keratinocytes
  publication-title: Biol. Pharm. Bull.
– volume: 15
  start-page: 316
  year: 2002
  end-page: 320
  article-title: Photocarcinogenesis: UVA vs. UVB radiation
  publication-title: Skin Pharmacol. Appl. Skin Physiol.
– volume: 7
  start-page: d1024
  year: 2002
  end-page: d1043
  article-title: UV damage, DNA repair and skin carcinogenesis
  publication-title: Front Biosci.
– volume: 286
  start-page: 1897
  year: 1999
  end-page: 1905
  article-title: Quality control by DNA repair
  publication-title: Science
– volume: 40
  start-page: 465
  year: 1984
  end-page: 471
  article-title: Antibodies to UV irradiated DNA: The monitoring of DNA damage by ELISA and indirect immunofluorescence
  publication-title: Photochem. Photobiol.
– volume: 21
  start-page: 381
  year: 2001
  end-page: 406
  article-title: Inhibition of carcinogenesis by dietary polyphenolic compounds
  publication-title: Annu. Rev. Nutr.
– volume: 33
  start-page: 2
  year: 2001
  end-page: 16
  article-title: Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential
  publication-title: Indian J. Pharmacol.
– volume: 127
  start-page: 222
  year: 2007
  end-page: 232
  article-title: Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB‐mediated oxidative stress and apoptosis
  publication-title: J. Invest. Dermatol.
– volume: 5
  start-page: 418
  year: 2006
  end-page: 429
  article-title: Enhancement of UVB radiation‐mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes
  publication-title: Mol. Cancer Ther.
– volume: 46
  start-page: 5
  year: 1998
  end-page: 19
  article-title: Changes in biologically active ultraviolet radiation reaching the Earth’s surface
  publication-title: J. Photochem. Photobiol. B
– volume: 58
  start-page: 445
  year: 1983
  end-page: 450
  article-title: Internal filters: Prospects for UV‐acclimation in higher plants
  publication-title: Physiol. Plant
– volume: 32
  start-page: 474
  year: 2002
  end-page: 480
  article-title: UV‐A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism
  publication-title: Free Radic. Biol. Med.
– volume: 82
  start-page: 574
  year: 2006
  end-page: 578
  article-title: Prevention of UV radiation‐induced premature skin aging in hairless mice by the novel compound Melanocin A
  publication-title: Photochem. Photobiol.
– volume: 1
  start-page: 181
  year: 2000
  end-page: 188
  article-title: Signal transduction pathways: Targets for chemoprevention of skin cancer
  publication-title: Lancet Oncol.
– volume: 356
  start-page: 77
  year: 2001
  end-page: 85
  article-title: Induction of gene expression via activator protein‐1 in the ascorbate protection against UV‐induced damage
  publication-title: Biochem. J.
– volume: 601
  start-page: 125
  year: 2006
  end-page: 136
  article-title: Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV‐ and BPDE‐induced killing and mutagenesis through inhibition of nucleotide excision repair
  publication-title: Mutat. Res.
– volume: 56
  start-page: 957
  year: 1989
  end-page: 968
  article-title: Expression and function of cyclin A during embryonic cell cycle progression
  publication-title: Cell
– volume: 374
  start-page: 131
  year: 1995
  end-page: 134
  article-title: Principles of CDK regulation
  publication-title: Nature
– volume: 16
  start-page: 853
  year: 1998
  end-page: 863
  article-title: Human keratin‐1.bcl‐2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation
  publication-title: Oncogene
– volume: 24
  start-page: 1379
  year: 2003
  end-page: 1388
  article-title: Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH‐1 hairless mice: Relationship to decreased fat and lipid peroxidation
  publication-title: Carcinogenesis
– volume: 63
  start-page: 492
  year: 1996
  end-page: 497
  article-title: Cell cycle kinetics following UVA irradiation in comparison to UVB and UVC irradiation
  publication-title: Photochem. Photobiol.
– ident: e_1_2_6_40_2
  doi: 10.1093/carcin/bgg095
– ident: e_1_2_6_16_2
  doi: 10.1101/gad.13.7.768
– ident: e_1_2_6_48_2
  doi: 10.1074/jbc.M505537200
– ident: e_1_2_6_11_2
  doi: 10.1002/(SICI)1097-4652(199811)177:2<324::AID-JCP14>3.0.CO;2-9
– ident: e_1_2_6_46_2
  doi: 10.1093/carcin/bgg188
– ident: e_1_2_6_39_2
  doi: 10.1189/jlb.69.5.719
– ident: e_1_2_6_64_2
  doi: 10.1038/354314a0
– ident: e_1_2_6_15_2
  doi: 10.1006/excr.2000.4833
– ident: e_1_2_6_45_2
  doi: 10.1016/S0891-5849(01)00829-2
– ident: e_1_2_6_28_2
  doi: 10.1146/annurev.nutr.21.1.381
– ident: e_1_2_6_35_2
  doi: 10.1074/jbc.M200401200
– ident: e_1_2_6_14_2
  doi: 10.1016/S0021-9258(19)74386-5
– ident: e_1_2_6_21_2
  doi: 10.1002/mc.10055
– ident: e_1_2_6_10_2
  doi: 10.1016/j.taap.2003.08.019
– volume: 33
  start-page: 2
  year: 2001
  ident: e_1_2_6_19_2
  article-title: Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential
  publication-title: Indian J. Pharmacol.
– ident: e_1_2_6_5_2
  doi: 10.1093/jnci/88.6.349
– ident: e_1_2_6_23_2
  doi: 10.1016/S1470-2045(00)00029-2
– ident: e_1_2_6_69_2
  doi: 10.1016/j.mrfmmm.2006.06.003
– ident: e_1_2_6_18_2
  doi: 10.1126/science.286.5446.1897
– ident: e_1_2_6_26_2
  doi: 10.1055/s-2007-969247
– ident: e_1_2_6_17_2
  doi: 10.1016/S0968-0004(00)89088-X
– ident: e_1_2_6_32_2
  doi: 10.1111/j.1751-1097.1984.tb04619.x
– ident: e_1_2_6_6_2
  doi: 10.2741/cleaver
– ident: e_1_2_6_12_2
  doi: 10.1016/S0006-2952(02)01386-2
– ident: e_1_2_6_7_2
  doi: 10.1016/S1383-5742(99)00025-3
– ident: e_1_2_6_47_2
  doi: 10.1158/1535-7163.MCT-05-0250
– ident: e_1_2_6_65_2
  doi: 10.1146/annurev.biochem.73.011303.073723
– ident: e_1_2_6_2_2
  doi: 10.1111/j.1751-1097.1999.tb08239.x
– ident: e_1_2_6_3_2
  doi: 10.1016/S1011-1344(98)00182-1
– volume: 8
  start-page: 619
  year: 1997
  ident: e_1_2_6_52_2
  article-title: Bcl‐x expression influences keratinocyte cell survival but not terminal differentiation
  publication-title: Cell Growth Differ.
– ident: e_1_2_6_24_2
  doi: 10.2741/afaq
– volume: 356
  start-page: 77
  year: 2001
  ident: e_1_2_6_44_2
  article-title: Induction of gene expression via activator protein‐1 in the ascorbate protection against UV‐induced damage
  publication-title: Biochem. J.
  doi: 10.1042/bj3560077
– ident: e_1_2_6_53_2
  doi: 10.1038/sj.cdd.4400455
– ident: e_1_2_6_55_2
  doi: 10.1016/0300-9084(96)88150-8
– ident: e_1_2_6_51_2
  doi: 10.1038/sj.onc.1201610
– volume: 12
  start-page: 1387
  year: 1996
  ident: e_1_2_6_57_2
  article-title: UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints
  publication-title: Oncogene
– ident: e_1_2_6_68_2
  doi: 10.1562/2005-07-26-RA-623
– ident: e_1_2_6_36_2
  doi: 10.1038/nrc883
– ident: e_1_2_6_49_2
  doi: 10.1248/bpb.30.32
– ident: e_1_2_6_58_2
  doi: 10.1038/sj.onc.1204883
– volume: 11
  start-page: 2151
  year: 1995
  ident: e_1_2_6_41_2
  article-title: Ultraviolet B irradiation‐induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase
  publication-title: Oncogene
– ident: e_1_2_6_29_2
  doi: 10.1002/ijc.20587
– ident: e_1_2_6_30_2
  doi: 10.1016/j.freeradbiomed.2004.01.001
– ident: e_1_2_6_9_2
  doi: 10.1016/j.bbcan.2005.04.001
– ident: e_1_2_6_34_2
  doi: 10.1016/S1568-7864(03)00002-8
– ident: e_1_2_6_38_2
  doi: 10.1039/B505311K
– ident: e_1_2_6_42_2
  doi: 10.1111/j.1399-3054.1983.tb04206.x
– ident: e_1_2_6_67_2
  doi: 10.1093/carcin/bgh152
– ident: e_1_2_6_56_2
  doi: 10.1111/j.1751-1097.1996.tb03075.x
– ident: e_1_2_6_66_2
  doi: 10.1111/j.0022-202X.2004.23560.x
– ident: e_1_2_6_27_2
  doi: 10.1093/jnci/89.8.556
– ident: e_1_2_6_43_2
  doi: 10.1083/jcb.106.3.761
– ident: e_1_2_6_63_2
  doi: 10.1016/0092-8674(89)90629-6
– ident: e_1_2_6_20_2
  doi: 10.1016/0031-9422(88)80264-4
– ident: e_1_2_6_59_2
  doi: 10.1038/359599a0
– ident: e_1_2_6_8_2
  doi: 10.1159/000064535
– ident: e_1_2_6_62_2
  doi: 10.1016/0092-8674(91)90293-8
– ident: e_1_2_6_31_2
  doi: 10.1016/S0076-6879(01)35253-9
– ident: e_1_2_6_33_2
  doi: 10.1111/j.1751-1097.1987.tb04798.x
– ident: e_1_2_6_25_2
  doi: 10.1016/S1040-8428(01)00185-8
– ident: e_1_2_6_13_2
  doi: 10.1074/jbc.274.25.17484
– ident: e_1_2_6_37_2
  doi: 10.1073/pnas.95.8.4386
– ident: e_1_2_6_60_2
  doi: 10.1038/374131a0
– ident: e_1_2_6_50_2
  doi: 10.1038/sj.jid.5700510
– ident: e_1_2_6_22_2
  doi: 10.1023/A:1021275330385
– ident: e_1_2_6_54_2
  doi: 10.1083/jcb.200208089
– volume-title: World Cancer Report
  year: 2003
  ident: e_1_2_6_4_2
– volume: 10
  start-page: 2079
  year: 1995
  ident: e_1_2_6_61_2
  article-title: The pRb‐related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes
  publication-title: Oncogene
SSID ssj0014971
Score 2.1582704
Snippet Many naturally occurring agents are believed to protect against UV‐induced skin damage. In this study, we have investigated the effects of naringenin (NG), a...
Many naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin (NG), a...
UV exposure also causes DNA damage including UV-induced CPD and 6-4PP and these adducts can be removed by nucleotide excision repair (NER). Monoclonal...
AbstractMany naturally occurring agents are believed to protect against UV-induced skin damage. In this study, we have investigated the effects of naringenin...
SourceID pubmedcentral
proquest
pubmed
crossref
wiley
istex
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 307
SubjectTerms Amino Acid Sequence
Apoptosis
Apoptosis - drug effects
Apoptosis - radiation effects
Biotechnology
Cell Line
Chemicals
Citrus
Deoxyribonucleic acid
DNA
DNA repair
Flavanones - pharmacology
Free radicals
Genetic disorders
Genome, Human
Human subjects
Humans
Keratinocytes - drug effects
Keratinocytes - radiation effects
Molecular Sequence Data
Monoclonal antibodies
Mortality
Pyrimidine Dimers - isolation & purification
Signal transduction
Ultraviolet Rays
SummonAdditionalLinks – databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwGLVg4_bCpbBRxsUPiLdoiR3H8RMqYVslRBWhbkxCKHJsp4vYktK0aP0x_Fc-58bGTZOQqqhS7CixT-xjf1_OQeilklTIjAjHNZQ7vgmIkyoVOkpoFphAepo2ZhN8MgmPj0Xc5uZUbVplNybWA7Uuld0j3yWUw48S9_X8q2NNo2xwtXXQuI42rUgCrTP34j6I4AveGOZRz7HfX_6SyMNsLpfgnYwhcOtO_6idnTZtQ5__iXr-nkF5kdnWU9P-vf98qPvobstJ8agB0QN0zRQDdLNxqVwP0O2oM4UboFvv21j8Q_R9Ius9wSIvcNyoPVR4LCM5xXVkAL-zes15Uao10Fk8mskcqCg-PHrj5IUGRGk8mpfzZVnlFZaFxnvFiYVghYGT4g_mrISXAJcZjtbqtExXwGINjtfWhgzmW4Pf5nbLHdvvY-oaB6Yoz8wnLWczs_j8CB3u702jsdOaPTgKFk0Mjm7mMkkCIoHVETc0yvgayIYIUm1Cz0uFyHSWsdBj3NdKpIRlJA0p1dwEOqVbaKMoC_MYOjnlBmr4IZXUJ8aVzMvSTNPQ90kaKD1EvOvkRLVK6NaQ4zS5sCICeDTReQuPpIZHcj5EXl9z3qiBXKHOqxpHfQW5-GKz6ThLPk4OkuhoCqNbxBJ3iHY6kCTtQFIlPUKG6EV_FvrchnWg2csVFLGib0BL_16Cu0BVQpcP0XYD2583H9olre9Dk1wCdF_Aqo9fPlPkJ7UKufUNEAKuyWroX7k9kngcw58n_3zaHXSnScyxyX5P0cZysTLP0A31bZlXi-f1a_4DaYVXWA
  priority: 102
  providerName: ProQuest
Title Naringenin Protects HaCaT Human Keratinocytes Against UVB-induced Apoptosis and Enhances the Removal of Cyclobutane Pyrimidine Dimers from the Genome
URI https://api.istex.fr/ark:/67375/WNG-CVTF5PC5-0/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1751-1097.2007.00255.x
https://www.ncbi.nlm.nih.gov/pubmed/18086244
https://www.proquest.com/docview/237237320
https://www.proquest.com/docview/20463515
https://www.proquest.com/docview/70413807
https://pubmed.ncbi.nlm.nih.gov/PMC2756997
Volume 84
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Agriculture Science Database
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: M0K
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/agriculturejournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: M7P
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: 7X7
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: 7RV
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: BENPR
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Science Database
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 20100131
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: M2P
  dateStart: 19981101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/sciencejournals
  providerName: ProQuest
– providerCode: PRVWIB
  databaseName: Wiley Online Library Full Collection 2020
  customDbUrl:
  eissn: 1751-1097
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0014971
  issn: 0031-8655
  databaseCode: DRFUL
  dateStart: 19970101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db5swELe2ZF8v-8i-sm6ZH6a9UYENGD-mNGmkrhGKkixvyGCzorUQhWZq3vYn7G3_3_6SnYGwZuukapqETgj7EPjO9s--8x1C72JBuUgIN0xFmWErlxhRHHtGzKXjKldYklbJJth47C0WPKj9n_RZmCo-RLPhpntGOV7rDi6iYreTM0e7Y3G2jUQI8Hgf8GSbgBo7LdQ-nAxnHxqbgs1ZlT-PWoY-jvmbX89179qZrNq63S-vQ6J_OlReBbrlTDV89D__8TF6WONV3K8U7Am6pbIOultlsNx00H1_mzCug-6d1Hb6p-j7WJT7hVma4aCKBFHgkfDFFJdWA3ysYzmnWR5vAOri_ieRAkzFs_nBj6_f0kyCvkncX-bLi7xICywyiQfZqVbQAgNixRN1nkMXwXmC_U18lkdrwLgKBxudpAxmY4UPU70hj_XpmZLjSGX5uXqGZsPB1B8ZdQoII4allAPUTExHEJcIwHrE9FSsbAkQhLuRVJ5lRZwnMkkcz3KYLWMeESchkUepZMqVEX2OWlmeqZcg64gp4LA9KqhNlCkcK4kSST3bJpEbyy5iW1mHcR0fXafpOAuvrJNAGpXNXksjLKURXnaR1XAuqxghN-B5X6pTwyBWn7WPHXPCj-Oj0J9PYczzndDsor2tvoX18FKEhDK4KIHSt00pSFsbe6C58zVU0aHgAKz-vQYzAcB4JuuiF5X2_vp4Ty90bRuaZEevmwo6JvluSZaelrHJdTYBzuGdTqnXN26PMBgFcPPqH_n20AO7dOTRzoGvUetitVZv0J34y0VarHroNpvMNV2wkno91D4YjINJrx4j4OmJeawpCTRlwU9Ny2Vq
linkProvider Wiley-Blackwell
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VFigXHuEVCnQPwM3C3rW99gGh4D5SpY2iKk0rIWTWu-vUorVDnEDzY_gJ_Edm_aLlpV56QIqiSN6xnNmZ2W89384g9EJw6vOY-IapKDNs5RIjEsIzhC8dV7nckrRsNsH6fe_oyB8soe_1WRhNq6xjYhGoZSb0O_LXhDL4UGK-nXw2dNMonVytO2iUVtFTi6-wY8vf7GzA9L4kZGtzGHSNqqmAIQCcO_BtxqbDiUs4oAdiekooW8Ki5ruRVJ5lRb4fyzh2PMththR-RJyYRB6lkilXRhTuew2tQBi3NIOM7Y-apIXts7JBH7UMfd7zF-KQo7ljPqvLJgKWr-stVavhip7Ysz9B3d8Zm-eRdLEUbt35z5R4F92uMDfulE5yDy2ptIVulF04Fy20GtRN71ro5l7FNbiPvvV58c4zTVI8KKtZ5LjLAz7EReYD93Q96iTNxALgOu6MeQJQGx-M3hlJKsFjJO5Mssksy5Mc81TizfRYu1iOAXPjfXWagZPjLMbBQpxk0RxQusKDhW6zBnhC4Y1EpxSwPv9TSGyrNDtV7yUfj9X0wwN0cCUqe4iW0yxVj8GoIqZAwvYopzZRJnesOIol9WybRK6QbcRqowpFVeldNxw5Cc_t-MAcS_aBNsewMMfwrI2sRnJSVju5hMyrwm4bAT79pNmCzAkP-9thMBpC9A6c0GyjtdoowypQ5mFjkW203lyFOddpK1B7NochuqgdwO6_j2AmQDHPZG30qHSTnw_v6S27bYNKLjhQM0BXV794JU2Oiyrrui-C78M9ncLVLq2PcNAdwI8n__y362i1O9zbDXd3-r01dKskIWli41O0PJvO1TN0XXyZJfn0eRFiMPp41e74A95xtAc
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VFgoXHuEVCnQPwM2qvWt77QNCwWmaKhBZKH1ICJn17jq1aO0QJ9D8GH4I_45ZP0LLS730gBRFkbxjObMzs996vp1B6Jng1OcJ8Q1TUWbYyiVGLIRnCF86rnK5JWnVbIINh97hoR-uoO_NWRhNq2xiYhmoZS70O_ItQhl8KDG3kpoVEXZ7ryafDd1ASidam24alYUM1OIr7N6Kl7tdmOrnhPS2R0HfqBsMGAKAugPfZmI6nLiEA5IgpqeEsiUscL4bS-VZVuz7iUwSx7McZkvhx8RJSOxRKplyZUzhvlfQGtM1y0vWYLhMYNg-q5r1UcvQZz9_IRE5mkfms6aEIuD6pvZSvTKu6Uk-_RPs_Z29eRZVl8ti79Z_rNDb6GaNxXGncp47aEVlLXSt6s65aKHrQdMMr4XW39YchLvo25CX70KzNMNhVeWiwH0e8BEuMyJ4oOtUp1kuFgDjcWfMU4DgeG__tZFmEjxJ4s4kn8zyIi0wzyTezo606xUYsDh-p05ycH6cJzhYiOM8ngN6Vzhc6PZrgDMU7qY61YD1uaBSYkdl-Yl6L_l4rKYf7qG9S1HZfbSa5Zl6CAYWMwUStkc5tYkyuWMlcSKpZ9skdoVsI9YYWCTqCvC6EclxdGYnCKZZsRK0aUalaUanbWQtJSdVFZQLyLwobXgpwKefNIuQOdHBcCcK9kcQ1QMnMttoozHQqA6gRbS0zjbaXF6FOdfpLFB7PochutgdwPG_j2AmQDTPZG30oHKZnw_v6a28bYNKzjnTcoCuun7-SpYeldXXdb8E34d7OqXbXVgfUdgP4cejf_7bTbQOXhi92R0ONtCNipuk-Y6P0epsOldP0FXxZZYW06dltMHo42V74w_JkLyp
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Naringenin+Protects+HaCaT+Human+Keratinocytes+Against+UVB-induced+Apoptosis+and+Enhances+the+Removal+of+Cyclobutane+Pyrimidine+Dimers+from+the+Genome&rft.jtitle=Photochemistry+and+photobiology&rft.au=El-Mahdy%2C+Mohamed+A.&rft.au=Zhu%2C+Qianzheng&rft.au=Wang%2C+Qi-En&rft.au=Wani%2C+Gulzar&rft.date=2008-03-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0031-8655&rft.eissn=1751-1097&rft.volume=84&rft.issue=2&rft.spage=307&rft.epage=316&rft_id=info:doi/10.1111%2Fj.1751-1097.2007.00255.x&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_CVTF5PC5_0
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0031-8655&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0031-8655&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0031-8655&client=summon