Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

Summary Purpose: Previous studies have shown that inhibition of the mammalian target of rapamycin (mTOR) pathway with rapamycin prevents epileptogenesis after pharmacologically induced status epilepticus (SE) in rat models of temporal lobe epilepsy. Because rapamycin is also known for its immunosup...

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Bibliographic Details
Published in:	Epilepsia (Copenhagen) Vol. 53; no. 7; pp. 1254 - 1263
Main Authors:	van Vliet, Erwin A., Forte, Grazia, Holtman, Linda, den Burger, Jeroen C. G., Sinjewel, Arno, de Vries, Helga E., Aronica, Eleonora, Gorter, Jan A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.07.2012 Wiley-Blackwell Wiley Subscription Services, Inc
Subjects:	Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects CD11b Antigen - metabolism Cytokines - blood Disease Models, Animal Drug Administration Schedule Electric Stimulation - adverse effects Electroencephalography Gliosis Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Immunosuppressive Agents - therapeutic use Inflammation Male Medical sciences Microglia - drug effects Microglia - metabolism Monocytes - drug effects Monocytes - metabolism Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Phosphopyruvate Hydratase - metabolism Rats Rats, Sprague-Dawley Seizures - drug therapy Seizures - etiology Signal Transduction - drug effects Sirolimus - blood Sirolimus - therapeutic use Statistics as Topic Statistics, Nonparametric Status epilepticus Status Epilepticus - blood Status Epilepticus - drug therapy Status Epilepticus - etiology Status Epilepticus - pathology Temporal lobe epilepsy Time Factors TOR Serine-Threonine Kinases - metabolism Vimentin - metabolism Antineoplastic agent Nervous system diseases Sirolimus Blood―brain barrier Neuroglia Central nervous system Complex partial epilepsy Lactone Inflammation Macrolide Blood brain barrier Encephalon Macrocycle Cerebral disorder Microglia Antibiotic Gliosis Subintrant crisis Central nervous system disease Temporal lobe epilepsy Protein synthesis inhibitor Immunosuppressive agent Status epilepticus
ISSN:	0013-9580, 1528-1167, 1528-1167
Online Access:	Get full text
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