Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Topoisomerase 1 (Top1) inhibition is believed to mediate cellular toxicity by trapping Top1 on nicked DNA, leading to double-strand break formation during replication. New studies show that clinically relevant doses of Top1 poisons lead instead to extensive replication-fork reversal that is mediated...

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Bibliographic Details
Published in:	Nature structural & molecular biology Vol. 19; no. 4; pp. 417 - 423
Main Authors:	Ray Chaudhuri, Arnab, Hashimoto, Yoshitami, Herrador, Raquel, Neelsen, Kai J, Fachinetti, Daniele, Bermejo, Rodrigo, Cocito, Andrea, Costanzo, Vincenzo, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2012 Nature Publishing Group
Subjects:	631/337/1427 631/337/151 631/67/1059/99 Adenosine diphosphate Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Camptothecin - pharmacology Cancer Cell Line Cellular biology Chemotherapy Chromosomes Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA Repair - drug effects DNA replication DNA Replication - drug effects DNA Topoisomerases, Type I - metabolism Enzymes Genetic aspects Humans Life Sciences Mammals Membrane Biology Nucleic Acid Conformation - drug effects Physiological aspects Poisons Poly(ADP-ribose) Polymerases - metabolism Protein Structure Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - drug effects Topoisomerase I Inhibitors - pharmacology Topoisomerases Toxicity Xenopus laevis Xenopus laevis - metabolism Yeast Yeasts United States
ISSN:	1545-9993, 1545-9985, 1545-9985
Online Access:	Get full text
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