Emerging Role of cAMP/AMPK Signaling

The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochond...

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Veröffentlicht in:Cells (Basel, Switzerland) Jg. 11; H. 2; S. 308
Hauptverfasser: Aslam, Muhammad, Ladilov, Yury
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 17.01.2022
MDPI
Schlagworte:
Adenosine
Adenylate cyclase
adenylyl cyclase
Aging
AMP-Activated Protein Kinases - metabolism
AMPK
Animals
Autophagy
Binding sites
cAMP
Cyclic AMP
Cyclic AMP - metabolism
Diabetes mellitus
Energy
Energy balance
Enzymes
EPAC
Epinephrine
Glucagon
Glucose metabolism
Homeostasis
Humans
Ischemia
Kinases
Lipid Metabolism
Localization
Mammalian cells
Metabolic disorders
Metabolism
Mitochondria
mitophagy
Models, Biological
Phosphatase
Phosphorylation
Physiology
PKA
Protein Biosynthesis
Protein kinase
Proteins
Regulation
Review
Sensors
Signal Transduction
mitophagy
autophagy
PKA
adenylyl cyclase
AMPK
cAMP
EPAC
ISSN:2073-4409, 2073-4409
Online-Zugang:Volltext
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Zusammenfassung:The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis. At the cellular level, AMPK supports numerous processes required for energy and redox homeostasis, including mitochondrial biogenesis, autophagy, and glucose and lipid metabolism. Thus, understanding the pathways regulating AMPK activity is crucial for developing strategies to treat metabolic disorders. Mounting evidence suggests the presence of a link between cyclic AMP (cAMP) and AMPK signaling. cAMP signaling is known to be activated in circumstances of physiological and metabolic stress due to the release of stress hormones, such as adrenaline and glucagon, which is followed by activation of membrane-bound adenylyl cyclase and elevation of cellular cAMP. Because the majority of physiological stresses are associated with elevated energy consumption, it is not surprising that activation of cAMP signaling may promote AMPK activity. Aside from the physiological role of the cAMP/AMPK axis, numerous reports have suggested its role in several pathologies, including inflammation, ischemia, diabetes, obesity, and aging. Furthermore, novel reports have provided more mechanistic insight into the regulation of the cAMP/AMPK axis. In particular, the role of distinct cAMP microdomains generated by soluble adenylyl cyclase in regulating basal and induced AMPK activity has recently been demonstrated. In the present review, we discuss current advances in the understanding of the regulation of the cAMP/AMPK axis and its role in cellular homeostasis and explore some translational aspects.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells11020308