Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients

Cases of iatrogenic prion disease have been reported from corneal transplants, yet the distribution and levels of prions throughout the eye remain unknown. This study probes the occurrence, level, and distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jakob disease (sCJD). We t...

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Bibliographic Details
Published in:	mBio Vol. 9; no. 6
Main Authors:	Orrù, Christina D., Soldau, Katrin, Cordano, Christian, Llibre-Guerra, Jorge, Green, Ari J., Sanchez, Henry, Groveman, Bradley R., Edland, Steven D., Safar, Jiri G., Lin, Jonathan H., Caughey, Byron, Geschwind, Michael D., Sigurdson, Christina J.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 20.11.2018
Subjects:	Aged Apraxia Autopsies Autopsy Biohazards Brain - pathology Brain research Clinical Science and Epidemiology Cornea Corneal transplantation Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - pathology eye Eye - pathology Eye lens Female Humans Iatrogenesis Immunohistochemistry Male Memory Middle Aged Mutation Optic nerve Patients prion Prion Diseases - diagnosis Prion protein Prions Prions - isolation & purification Retina Retina - pathology RT-QuIC Seeds Transmissible spongiform encephalopathy eye prion Creutzfeldt-Jakob disease RT-QuIC
ISSN:	2161-2129, 2150-7511, 2150-7511
Online Access:	Get full text
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