RNA-binding protein nucleolin in disease

Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRN...

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Bibliographic Details
Published in:RNA biology Vol. 9; no. 6; pp. 799 - 808
Main Authors: Abdelmohsen, Kotb, Gorospe, Myriam
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01.06.2012
Landes Bioscience
Subjects:
Animals
apoptosis
AU-rich elements
Binding
Biology
Bioscience
Calcium
Cancer
Cell
cell membranes
cell nucleolus
cell proliferation
Cycle
DNA
G-rich sequences
gene expression
Gene Expression Regulation
Humans
Landes
metabolism
microRNA
Molecular Targeted Therapy
mRNA stability
mRNA translation
Neoplasms - drug therapy
Neoplasms - metabolism
Nucleolin
Organogenesis
Phosphoproteins - physiology
post-transcriptional gene regulation
Protein Processing, Post-Translational
Protein Transport
Proteins
Review
ribosomes
RNA Stability
RNA-binding proteins
RNA-Binding Proteins - physiology
therapy
transcriptome
ISSN:1547-6286, 1555-8584, 1555-8584
Online Access:Get full text
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Summary:Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRNA stability and translation, and microRNA processing. Nucleolin's implication in disease is linked to its ability to associate with target RNAs via its four RNA-binding domains and its arginine/glycin-rich domain. By modulating the post-transcriptional fate of target mRNAs, which typically bear AU-rich and/or G-rich elements, nucleolin has been linked to cellular events that influence disease, notably cell proliferation and protection against apoptotic death. Through its diverse RNA functions, nucleolin is increasingly implicated in pathological processes, particularly cancer and viral infection. Here, we review the RNA-binding activities of nucleolin, its influence on gene expression patterns, and its impact upon diseases. We also discuss the rising interest in targeting nucleolin therapeutically.
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ISSN:1547-6286
1555-8584
1555-8584
DOI:10.4161/rna.19718