RNA-binding protein nucleolin in disease

Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRN...

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Vydané v:	RNA biology Ročník 9; číslo 6; s. 799 - 808
Hlavní autori:	Abdelmohsen, Kotb, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 01.06.2012 Landes Bioscience
Predmet:	Animals apoptosis AU-rich elements Binding Biology Bioscience Calcium Cancer Cell cell membranes cell nucleolus cell proliferation Cycle DNA G-rich sequences gene expression Gene Expression Regulation Humans Landes metabolism microRNA Molecular Targeted Therapy mRNA stability mRNA translation Neoplasms - drug therapy Neoplasms - metabolism Nucleolin Organogenesis Phosphoproteins - physiology post-transcriptional gene regulation Protein Processing, Post-Translational Protein Transport Proteins Review ribosomes RNA Stability RNA-binding proteins RNA-Binding Proteins - physiology therapy transcriptome
ISSN:	1547-6286, 1555-8584, 1555-8584
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Popis
Shrnutí:	Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA metabolism, and participates extensively in RNA regulatory mechanisms, including transcription, ribosome assembly, mRNA stability and translation, and microRNA processing. Nucleolin's implication in disease is linked to its ability to associate with target RNAs via its four RNA-binding domains and its arginine/glycin-rich domain. By modulating the post-transcriptional fate of target mRNAs, which typically bear AU-rich and/or G-rich elements, nucleolin has been linked to cellular events that influence disease, notably cell proliferation and protection against apoptotic death. Through its diverse RNA functions, nucleolin is increasingly implicated in pathological processes, particularly cancer and viral infection. Here, we review the RNA-binding activities of nucleolin, its influence on gene expression patterns, and its impact upon diseases. We also discuss the rising interest in targeting nucleolin therapeutically.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1547-6286 1555-8584 1555-8584
DOI:	10.4161/rna.19718