The Reduction of R1, a Novel Repressor Protein for Monoamine Oxidase A, in Major Depressive Disorder

The novel transcriptional repressor protein, R1 (JPO2/CDCA7L/RAM2), inhibits monoamine oxidase A (MAO A) gene expression and influences cell proliferation and survival. MAO A is implicated in several neuropsychiatric illnesses and highly elevated in major depressive disorder (MDD); however, whether...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 36; no. 10; pp. 2139 - 2148
Main Authors:	Johnson, Shakevia, Stockmeier, Craig A, Meyer, Jeffrey H, Austin, Mark C, Albert, Paul R, Wang, Junming, May, Warren L, Rajkowska, Grazyna, Overholser, James C, Jurjus, George, Dieter, Lesa, Johnson, Chandra, Sittman, Donald B, Ou, Xiao-Ming
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2011 Nature Publishing Group
Subjects:	631/80/304 692/699/476/1414 Apoptosis - genetics Apoptosis - physiology Behavioral Sciences Biological Psychology Cell death Cell growth Depressive Disorder, Major - enzymology Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Female Humans Male Medicine Medicine & Public Health Mental depression Middle Aged Monoamine Oxidase - biosynthesis Monoamine Oxidase - deficiency Monoamine Oxidase - genetics Neurosciences Original original-article Pharmacotherapy Protein expression Proteins Psychiatry Repressor Proteins - antagonists & inhibitors Repressor Proteins - physiology Retrospective Studies Canada United States > US treatment selective serotonin reuptake inhibitor major depressive disorder transcriptional repressor protein prefrontal cortex monoamine oxidase
ISSN:	0893-133X, 1740-634X, 1740-634X
Online Access:	Get full text
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