Adenosine Regulates the Proinflammatory Signaling Function of Thrombin in Endothelial Cells

The plasma level of the regulatory metabolite adenosine increases during the activation of coagulation and inflammation. Here we investigated the effect of adenosine on modulation of thrombin‐mediated proinflammatory responses in HUVECs. We found that adenosine inhibits the barrier‐disruptive effect...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 229; no. 9; pp. 1292 - 1300
Main Authors:	Hassanian, Seyed Mahdi, Dinarvand, Peyman, Rezaie, Alireza R.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01.09.2014 Wiley Subscription Services, Inc
Subjects:	Adenosine - metabolism Adenosine - pharmacology Adenosine A2 Receptor Agonists - metabolism Adenosine A2 Receptor Agonists - pharmacology Adenosine A2 Receptor Antagonists - pharmacology Adhesion Blood Coagulation - drug effects Capillary Permeability Cell Adhesion Cells, Cultured Coagulation Coculture Techniques Cyclic AMP - metabolism Dose-Response Relationship, Drug E-Selectin - metabolism Enzyme Activation Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - immunology Human Umbilical Vein Endothelial Cells - metabolism Humans Inflammation - blood Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Intercellular Adhesion Molecule-1 - metabolism Metabolites NF-kappa B - metabolism Protein Transport Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Receptor, Adenosine A2B - metabolism rhoA GTP-Binding Protein - metabolism RNA Interference Signal Transduction - drug effects Thrombin - metabolism Thrombin - pharmacology Transfection Translocation Vascular Cell Adhesion Molecule-1 - metabolism
ISSN:	0021-9541, 1097-4652, 1097-4652
Online Access:	Get full text
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