Multiple sclerosis following SARS-CoV-2 infection

•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented.•Viral infections strongly relate to MS onset and its relapses.•SARS-CoV-2 can play a role in the triggering of demyelinating diseases.•Systemic immune response against SARS-CoV-2 could reach CNS leading to demyelination....

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Published in:	Multiple sclerosis and related disorders Vol. 45; p. 102377
Main Authors:	Palao, M., Fernández-Díaz, E., Gracia-Gil, J., Romero-Sánchez, C.M., Díaz-Maroto, I., Segura, T.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.10.2020
Subjects:	Adult Betacoronavirus Coronavirus Infections - complications COVID-19 Demyelinating disease Female Humans MHV-59 Multiple Sclerosis - epidemiology Multiple Sclerosis - pathology Neurology Optic neuritis Original Pandemics Pneumonia, Viral - complications SARS-CoV-2 COVID-19 Demyelinating disease SARS-CoV-2 MHV-59 Optic neuritis
ISSN:	2211-0348, 2211-0356, 2211-0356
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Abstract	•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented.•Viral infections strongly relate to MS onset and its relapses.•SARS-CoV-2 can play a role in the triggering of demyelinating diseases.•Systemic immune response against SARS-CoV-2 could reach CNS leading to demyelination. SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease.
AbstractList	•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented.•Viral infections strongly relate to MS onset and its relapses.•SARS-CoV-2 can play a role in the triggering of demyelinating diseases.•Systemic immune response against SARS-CoV-2 could reach CNS leading to demyelination. SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease. • The first case of multiple sclerosis (MS) shortly after COVID-19 is presented. • Viral infections strongly relate to MS onset and its relapses. • SARS-CoV-2 can play a role in the triggering of demyelinating diseases. • Systemic immune response against SARS-CoV-2 could reach CNS leading to demyelination. SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease. SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease.SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease. SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous system (CNS) injuries. We present a patient affected by Covid-19 who initially consulted for decreased visual acuity. The MRI showed inflammation in the right optic nerve and demyelinating lesions in the CNS. We speculate that an immune mechanism induced by SARS-CoV-2, which can activate lymphocytes and an inflammatory response, plays a role in the clinical onset of the disease. This pathogen may be associated with either the triggering or the exacerbation of inflammatory/demyelinating disease. Highlights•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented. •Viral infections strongly relate to MS onset and its relapses. •SARS-CoV-2 can play a role in the triggering of demyelinating diseases. •Systemic immune response against SARS-CoV-2 could reach CNS leading to demyelination.
ArticleNumber	102377
Author	Segura, T. Palao, M. Gracia-Gil, J. Romero-Sánchez, C.M. Fernández-Díaz, E. Díaz-Maroto, I.
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32698095$$D View this record in MEDLINE/PubMed
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Keywords	COVID-19 Demyelinating disease SARS-CoV-2 MHV-59 Optic neuritis
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Snippet	•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented.•Viral infections strongly relate to MS onset and its relapses.•SARS-CoV-2 can... Highlights•The first case of multiple sclerosis (MS) shortly after COVID-19 is presented. •Viral infections strongly relate to MS onset and its relapses.... SARS-CoV-2 infection can produce neurological features. The most common are headache, anosmia and dysgeusia but patients may also develop other central nervous... • The first case of multiple sclerosis (MS) shortly after COVID-19 is presented. • Viral infections strongly relate to MS onset and its relapses. • SARS-CoV-2...
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SubjectTerms	Adult Betacoronavirus Coronavirus Infections - complications COVID-19 Demyelinating disease Female Humans MHV-59 Multiple Sclerosis - epidemiology Multiple Sclerosis - pathology Neurology Optic neuritis Original Pandemics Pneumonia, Viral - complications SARS-CoV-2
Title	Multiple sclerosis following SARS-CoV-2 infection
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